A rearrangement between the PML and RAR-α genes underlies the acute promyelocytic leukemia (APL) specific t(15;17) translocation, leading to the production of a chimeric mRNA. Recent development of a reverse-transcription polymerase chain reaction (RT-PCR) assay for the PML/RAR-α hybrid has proven useful for rapid diagnosis and monitoring of minimal residual disease (MRD) in APL patients. Preliminary studies in which the prognostic significance of RT-PCR was evaluated indicate that this test may identify patients at high risk of relapse.
|Number of pages||3|
|Publication status||Published - Jul 1994|
ASJC Scopus subject areas
- Cancer Research