Monitoring of treatment outcome in acute promyelocytic leukemia by RT-PCR

Daniela Diverio, Pier Paolo Pandolfi, Vincenzo Rossi, Andrea Biondi, Pier Giuseppe Pelicci, Francesco Lo Coco

Research output: Contribution to journalArticlepeer-review

Abstract

A rearrangement between the PML and RAR-α genes underlies the acute promyelocytic leukemia (APL) specific t(15;17) translocation, leading to the production of a chimeric mRNA. Recent development of a reverse-transcription polymerase chain reaction (RT-PCR) assay for the PML/RAR-α hybrid has proven useful for rapid diagnosis and monitoring of minimal residual disease (MRD) in APL patients. Preliminary studies in which the prognostic significance of RT-PCR was evaluated indicate that this test may identify patients at high risk of relapse.

Original languageEnglish
Pages (from-to)1105-1107
Number of pages3
JournalLeukemia
Volume8
Issue number7
Publication statusPublished - Jul 1994

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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