Monitoring response to antiviral therapy for patients with chronic hepatitis C virus infection by a core-antigen assay

Chiara Rebucci, Antonella Cerino, Agostino Cividini, Letizia Timo, Milena Furione, Mario U. Mondelli

Research output: Contribution to journalArticlepeer-review

Abstract

A recently released immunoassay detecting total serum hepatitis C virus (HCV) core antigen was used to prospectively monitor virological responses to antiviral treatment in patients with chronic HCV infection. Sustained responders cleared core protein from serum within the first month of therapy and maintained stably negative values for the entire duration of follow-up after treatment discontinuation. However, patients who relapsed or failed to respond showed transient negative values and could not be accurately discriminated either because of the intrinsic lower sensitivity of the core-antigen assay than those of molecular assays or because of differentially regulated secretion of immunoreactive core protein from infected hepatocytes.

Original languageEnglish
Pages (from-to)3881-3884
Number of pages4
JournalJournal of Clinical Microbiology
Volume41
Issue number8
DOIs
Publication statusPublished - Aug 1 2003

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Fingerprint Dive into the research topics of 'Monitoring response to antiviral therapy for patients with chronic hepatitis C virus infection by a core-antigen assay'. Together they form a unique fingerprint.

Cite this