Monitoring the quality of laboraties and the prevalence of resistance to antituberculosis drugs

Italy, 1998-2000

G. B. Migliori, R. Centis, L. Fattorini, G. Besozzi, C. Saltini, G. Orefici, C. Piersimoni, A. Gori, A. Cassone, A. De Santis, V. Giorgio, P. Vinciguerra, G. Angarano, L. Petrozzi, D. Costa, F. Gozzellino, A. Perboni, D. Marchetti, M. L. Moro, A. Pascali & 79 others F. Falcone, V. Mariano, F. Rizza, P. Pretto, F. Turano, A. Matteelli, G. P. Carosi, S. Tedoldi, G. Pinsi, A. G. Farris, B. Farris, A. Spanevello, C. Foschi, G. Trucco, S. Aiolfi, T. Ceruti, M. Parpanesi, S. Calabro, G. Felisatti, E. Tortoli, F. Nutini, G. Montini, F. Fiorentini, V. D'Ambrosio, A. Ceraminiello, S. Bernorio, L. Buono, P. Montesano, E. Vinci, E. Sabato, S. Gamba, L. R. Codecasa, F. Mandler, V. Penati, P. Vaccarino, G. Bertoli, F. Rupianesi, M. Losi, L. Richeldi, G. Ferrara, E. Minuccio, G. Napolitano, G. L. Molinari, L. Saini, G. L. Garzone, C. Vertuccio, S. Marcias, M. Menozzi, P. Marone, V. Peona, C. Nascimbene, A. Pasi, A. Cascina, L. Casali, A. Monaco, S. Pauluzzi, O. Penza, M. B. Pasticci, F. Bistoni, T. Sposini, V. Colorizio, P. Bottrighi, A. Orsi, L. Schiavi, G. Macor, G. Moretti, R. Fatigante, A. Barbaro, G. Agati, F. Zaccara, S. Viola, R. Le Donne, G. Farinelli, D. Mancini, M. Ermeti, G. Orefici, E. Iona, M. Tronci, A. Bisetti

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In 1998 a network of 20 regional tuberculosis (TB) laboratories (the Italian Multicentre Study on Resistance to Antituberculosis drugs (SMIRA) network) was established in Italy to implement proficiency testing and to monitor the prevalence of drug resistance nationwide. The network managed 30% of all TB cases reported in Italy each year. The aim of the present report is to describe: 1) the accuracy of drug-susceptibility testing in the network; 2) the prevalence of drug resistance for the period 1998-2000. Data were collected from the network laboratories. Sensitivity to streptomycin and ethambutol increased from the first survey (1998-1999) to the second survey (2000) from 87.7 to 91.9%. Specificity, predictive values for resistance and susceptibility, efficiency and reproducibility were consistent in both surveys. In previously untreated cases, the prevalence of multidrug-resistance was the same in both surveys (1.2%), while a slight decrease from the first to the second survey was observed for monoresistance to rifampicin (from 0.8 to 0.4%) and isoniazid (from 2.9 to 2%,). The significant association found between isoniazid resistance and immigration is a useful indicator for both clinicians managing individual tuberculosis cases and public health services planning control strategies.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalEuropean Respiratory Journal
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

Fingerprint

Italy
Tuberculosis
Pharmaceutical Preparations
Isoniazid
Drug Resistance
Ethambutol
Health Planning
United States Public Health Service
Emigration and Immigration
Multiple Drug Resistance
Streptomycin
Rifampin
Multicenter Studies
Surveys and Questionnaires

Keywords

  • Drug
  • Immigrant
  • Prevalence of resistance
  • Proficiency testing
  • Susceptibility testing
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Monitoring the quality of laboraties and the prevalence of resistance to antituberculosis drugs : Italy, 1998-2000. / Migliori, G. B.; Centis, R.; Fattorini, L.; Besozzi, G.; Saltini, C.; Orefici, G.; Piersimoni, C.; Gori, A.; Cassone, A.; De Santis, A.; Giorgio, V.; Vinciguerra, P.; Angarano, G.; Petrozzi, L.; Costa, D.; Gozzellino, F.; Perboni, A.; Marchetti, D.; Moro, M. L.; Pascali, A.; Falcone, F.; Mariano, V.; Rizza, F.; Pretto, P.; Turano, F.; Matteelli, A.; Carosi, G. P.; Tedoldi, S.; Pinsi, G.; Farris, A. G.; Farris, B.; Spanevello, A.; Foschi, C.; Trucco, G.; Aiolfi, S.; Ceruti, T.; Parpanesi, M.; Calabro, S.; Felisatti, G.; Tortoli, E.; Nutini, F.; Montini, G.; Fiorentini, F.; D'Ambrosio, V.; Ceraminiello, A.; Bernorio, S.; Buono, L.; Montesano, P.; Vinci, E.; Sabato, E.; Gamba, S.; Codecasa, L. R.; Mandler, F.; Penati, V.; Vaccarino, P.; Bertoli, G.; Rupianesi, F.; Losi, M.; Richeldi, L.; Ferrara, G.; Minuccio, E.; Napolitano, G.; Molinari, G. L.; Saini, L.; Garzone, G. L.; Vertuccio, C.; Marcias, S.; Menozzi, M.; Marone, P.; Peona, V.; Nascimbene, C.; Pasi, A.; Cascina, A.; Casali, L.; Monaco, A.; Pauluzzi, S.; Penza, O.; Pasticci, M. B.; Bistoni, F.; Sposini, T.; Colorizio, V.; Bottrighi, P.; Orsi, A.; Schiavi, L.; Macor, G.; Moretti, G.; Fatigante, R.; Barbaro, A.; Agati, G.; Zaccara, F.; Viola, S.; Le Donne, R.; Farinelli, G.; Mancini, D.; Ermeti, M.; Orefici, G.; Iona, E.; Tronci, M.; Bisetti, A.

In: European Respiratory Journal, Vol. 21, No. 1, 01.01.2003, p. 129-134.

Research output: Contribution to journalArticle

Migliori, GB, Centis, R, Fattorini, L, Besozzi, G, Saltini, C, Orefici, G, Piersimoni, C, Gori, A, Cassone, A, De Santis, A, Giorgio, V, Vinciguerra, P, Angarano, G, Petrozzi, L, Costa, D, Gozzellino, F, Perboni, A, Marchetti, D, Moro, ML, Pascali, A, Falcone, F, Mariano, V, Rizza, F, Pretto, P, Turano, F, Matteelli, A, Carosi, GP, Tedoldi, S, Pinsi, G, Farris, AG, Farris, B, Spanevello, A, Foschi, C, Trucco, G, Aiolfi, S, Ceruti, T, Parpanesi, M, Calabro, S, Felisatti, G, Tortoli, E, Nutini, F, Montini, G, Fiorentini, F, D'Ambrosio, V, Ceraminiello, A, Bernorio, S, Buono, L, Montesano, P, Vinci, E, Sabato, E, Gamba, S, Codecasa, LR, Mandler, F, Penati, V, Vaccarino, P, Bertoli, G, Rupianesi, F, Losi, M, Richeldi, L, Ferrara, G, Minuccio, E, Napolitano, G, Molinari, GL, Saini, L, Garzone, GL, Vertuccio, C, Marcias, S, Menozzi, M, Marone, P, Peona, V, Nascimbene, C, Pasi, A, Cascina, A, Casali, L, Monaco, A, Pauluzzi, S, Penza, O, Pasticci, MB, Bistoni, F, Sposini, T, Colorizio, V, Bottrighi, P, Orsi, A, Schiavi, L, Macor, G, Moretti, G, Fatigante, R, Barbaro, A, Agati, G, Zaccara, F, Viola, S, Le Donne, R, Farinelli, G, Mancini, D, Ermeti, M, Orefici, G, Iona, E, Tronci, M & Bisetti, A 2003, 'Monitoring the quality of laboraties and the prevalence of resistance to antituberculosis drugs: Italy, 1998-2000', European Respiratory Journal, vol. 21, no. 1, pp. 129-134. https://doi.org/10.1183/09031936.03.00047402
Migliori, G. B. ; Centis, R. ; Fattorini, L. ; Besozzi, G. ; Saltini, C. ; Orefici, G. ; Piersimoni, C. ; Gori, A. ; Cassone, A. ; De Santis, A. ; Giorgio, V. ; Vinciguerra, P. ; Angarano, G. ; Petrozzi, L. ; Costa, D. ; Gozzellino, F. ; Perboni, A. ; Marchetti, D. ; Moro, M. L. ; Pascali, A. ; Falcone, F. ; Mariano, V. ; Rizza, F. ; Pretto, P. ; Turano, F. ; Matteelli, A. ; Carosi, G. P. ; Tedoldi, S. ; Pinsi, G. ; Farris, A. G. ; Farris, B. ; Spanevello, A. ; Foschi, C. ; Trucco, G. ; Aiolfi, S. ; Ceruti, T. ; Parpanesi, M. ; Calabro, S. ; Felisatti, G. ; Tortoli, E. ; Nutini, F. ; Montini, G. ; Fiorentini, F. ; D'Ambrosio, V. ; Ceraminiello, A. ; Bernorio, S. ; Buono, L. ; Montesano, P. ; Vinci, E. ; Sabato, E. ; Gamba, S. ; Codecasa, L. R. ; Mandler, F. ; Penati, V. ; Vaccarino, P. ; Bertoli, G. ; Rupianesi, F. ; Losi, M. ; Richeldi, L. ; Ferrara, G. ; Minuccio, E. ; Napolitano, G. ; Molinari, G. L. ; Saini, L. ; Garzone, G. L. ; Vertuccio, C. ; Marcias, S. ; Menozzi, M. ; Marone, P. ; Peona, V. ; Nascimbene, C. ; Pasi, A. ; Cascina, A. ; Casali, L. ; Monaco, A. ; Pauluzzi, S. ; Penza, O. ; Pasticci, M. B. ; Bistoni, F. ; Sposini, T. ; Colorizio, V. ; Bottrighi, P. ; Orsi, A. ; Schiavi, L. ; Macor, G. ; Moretti, G. ; Fatigante, R. ; Barbaro, A. ; Agati, G. ; Zaccara, F. ; Viola, S. ; Le Donne, R. ; Farinelli, G. ; Mancini, D. ; Ermeti, M. ; Orefici, G. ; Iona, E. ; Tronci, M. ; Bisetti, A. / Monitoring the quality of laboraties and the prevalence of resistance to antituberculosis drugs : Italy, 1998-2000. In: European Respiratory Journal. 2003 ; Vol. 21, No. 1. pp. 129-134.
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TY - JOUR

T1 - Monitoring the quality of laboraties and the prevalence of resistance to antituberculosis drugs

T2 - Italy, 1998-2000

AU - Migliori, G. B.

AU - Centis, R.

AU - Fattorini, L.

AU - Besozzi, G.

AU - Saltini, C.

AU - Orefici, G.

AU - Piersimoni, C.

AU - Gori, A.

AU - Cassone, A.

AU - De Santis, A.

AU - Giorgio, V.

AU - Vinciguerra, P.

AU - Angarano, G.

AU - Petrozzi, L.

AU - Costa, D.

AU - Gozzellino, F.

AU - Perboni, A.

AU - Marchetti, D.

AU - Moro, M. L.

AU - Pascali, A.

AU - Falcone, F.

AU - Mariano, V.

AU - Rizza, F.

AU - Pretto, P.

AU - Turano, F.

AU - Matteelli, A.

AU - Carosi, G. P.

AU - Tedoldi, S.

AU - Pinsi, G.

AU - Farris, A. G.

AU - Farris, B.

AU - Spanevello, A.

AU - Foschi, C.

AU - Trucco, G.

AU - Aiolfi, S.

AU - Ceruti, T.

AU - Parpanesi, M.

AU - Calabro, S.

AU - Felisatti, G.

AU - Tortoli, E.

AU - Nutini, F.

AU - Montini, G.

AU - Fiorentini, F.

AU - D'Ambrosio, V.

AU - Ceraminiello, A.

AU - Bernorio, S.

AU - Buono, L.

AU - Montesano, P.

AU - Vinci, E.

AU - Sabato, E.

AU - Gamba, S.

AU - Codecasa, L. R.

AU - Mandler, F.

AU - Penati, V.

AU - Vaccarino, P.

AU - Bertoli, G.

AU - Rupianesi, F.

AU - Losi, M.

AU - Richeldi, L.

AU - Ferrara, G.

AU - Minuccio, E.

AU - Napolitano, G.

AU - Molinari, G. L.

AU - Saini, L.

AU - Garzone, G. L.

AU - Vertuccio, C.

AU - Marcias, S.

AU - Menozzi, M.

AU - Marone, P.

AU - Peona, V.

AU - Nascimbene, C.

AU - Pasi, A.

AU - Cascina, A.

AU - Casali, L.

AU - Monaco, A.

AU - Pauluzzi, S.

AU - Penza, O.

AU - Pasticci, M. B.

AU - Bistoni, F.

AU - Sposini, T.

AU - Colorizio, V.

AU - Bottrighi, P.

AU - Orsi, A.

AU - Schiavi, L.

AU - Macor, G.

AU - Moretti, G.

AU - Fatigante, R.

AU - Barbaro, A.

AU - Agati, G.

AU - Zaccara, F.

AU - Viola, S.

AU - Le Donne, R.

AU - Farinelli, G.

AU - Mancini, D.

AU - Ermeti, M.

AU - Orefici, G.

AU - Iona, E.

AU - Tronci, M.

AU - Bisetti, A.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - In 1998 a network of 20 regional tuberculosis (TB) laboratories (the Italian Multicentre Study on Resistance to Antituberculosis drugs (SMIRA) network) was established in Italy to implement proficiency testing and to monitor the prevalence of drug resistance nationwide. The network managed 30% of all TB cases reported in Italy each year. The aim of the present report is to describe: 1) the accuracy of drug-susceptibility testing in the network; 2) the prevalence of drug resistance for the period 1998-2000. Data were collected from the network laboratories. Sensitivity to streptomycin and ethambutol increased from the first survey (1998-1999) to the second survey (2000) from 87.7 to 91.9%. Specificity, predictive values for resistance and susceptibility, efficiency and reproducibility were consistent in both surveys. In previously untreated cases, the prevalence of multidrug-resistance was the same in both surveys (1.2%), while a slight decrease from the first to the second survey was observed for monoresistance to rifampicin (from 0.8 to 0.4%) and isoniazid (from 2.9 to 2%,). The significant association found between isoniazid resistance and immigration is a useful indicator for both clinicians managing individual tuberculosis cases and public health services planning control strategies.

AB - In 1998 a network of 20 regional tuberculosis (TB) laboratories (the Italian Multicentre Study on Resistance to Antituberculosis drugs (SMIRA) network) was established in Italy to implement proficiency testing and to monitor the prevalence of drug resistance nationwide. The network managed 30% of all TB cases reported in Italy each year. The aim of the present report is to describe: 1) the accuracy of drug-susceptibility testing in the network; 2) the prevalence of drug resistance for the period 1998-2000. Data were collected from the network laboratories. Sensitivity to streptomycin and ethambutol increased from the first survey (1998-1999) to the second survey (2000) from 87.7 to 91.9%. Specificity, predictive values for resistance and susceptibility, efficiency and reproducibility were consistent in both surveys. In previously untreated cases, the prevalence of multidrug-resistance was the same in both surveys (1.2%), while a slight decrease from the first to the second survey was observed for monoresistance to rifampicin (from 0.8 to 0.4%) and isoniazid (from 2.9 to 2%,). The significant association found between isoniazid resistance and immigration is a useful indicator for both clinicians managing individual tuberculosis cases and public health services planning control strategies.

KW - Drug

KW - Immigrant

KW - Prevalence of resistance

KW - Proficiency testing

KW - Susceptibility testing

KW - Tuberculosis

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U2 - 10.1183/09031936.03.00047402

DO - 10.1183/09031936.03.00047402

M3 - Article

VL - 21

SP - 129

EP - 134

JO - Scandinavian Journal of Respiratory Diseases

JF - Scandinavian Journal of Respiratory Diseases

SN - 0903-1936

IS - 1

ER -