Monitoring the rate of hospitalization before rotavirus immunization in Italy utilizing ICD9-CM regional databases

Federico Marchetti, Barouk Assael, Giovanni Gabutti, Alfredo Guarino, Pier Luigi Lopalco, Alessia Marocco, Franco Ruggeri, Lucina Titone, Alberto Tozzi, Giovanni Vitali Rosati, Carla Zotti, Elisabetta Franco

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Recently, two Rotavirus (RV) vaccines were licensed in Italy, rendering RV illness a vaccine preventable disease. To assess the RV hospitalization rate in Italy, a study focused on the Regional hospital discharge forms (HDD) databases was carried out. Results: Regional HDD databases from Piemonte, Veneto, Friuli-Venezia-Giulia and Marche were analyzed. A total of 434,335 hospitalizations were counted in the study timeframe and 13,234 VE diagnoses (3% of hospitalizations) were collected. A total of 8546 RVE cases (2% of hospitalizations, 64% of all VE) were observed, of which 1.2% were primary diagnoses (PD) and 0.8% secondary diagnosis (SD). The RVE hospitalization peak (4.9%) was observed at the age of 1 year (4.5% in 7-12 months of age) with a median hospital stay of 4.4 days (s.d ± 4.2). Two deaths (out of 8546 RVE cases) were identified. Patients and methods: Regional HDD databases with the diagnosis of viral enteritis (VE) and RV enteritis (RVE) (ICD9-CM code 00861-69 and 008.8) in any position of the first 20 discharge diagnoses in children aged less or equal to 5 years between 2001 and 2005 were requested. Conclusion: Despite some limitations due to the HDD synthetic contents and low potential for clinical interpretation, the Regional HDD databases, including PD and SD, may be a useful tool for monitoring the clinical impact of RV vaccination introduction in Italy.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalHuman Vaccines
Volume5
Issue number3
DOIs
Publication statusPublished - 2009

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Enteritis
Rotavirus
Italy
Immunization
Hospitalization
Databases
Rotavirus Vaccines
Length of Stay
Vaccination
Vaccines

Keywords

  • Database
  • Enteritis
  • Hospitalization ICD9-CM
  • Rotavirus
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Marchetti, F., Assael, B., Gabutti, G., Guarino, A., Luigi Lopalco, P., Marocco, A., ... Franco, E. (2009). Monitoring the rate of hospitalization before rotavirus immunization in Italy utilizing ICD9-CM regional databases. Human Vaccines, 5(3), 172-176. https://doi.org/10.4161/hv.5.3.6764

Monitoring the rate of hospitalization before rotavirus immunization in Italy utilizing ICD9-CM regional databases. / Marchetti, Federico; Assael, Barouk; Gabutti, Giovanni; Guarino, Alfredo; Luigi Lopalco, Pier; Marocco, Alessia; Ruggeri, Franco; Titone, Lucina; Tozzi, Alberto; Vitali Rosati, Giovanni; Zotti, Carla; Franco, Elisabetta.

In: Human Vaccines, Vol. 5, No. 3, 2009, p. 172-176.

Research output: Contribution to journalArticle

Marchetti, F, Assael, B, Gabutti, G, Guarino, A, Luigi Lopalco, P, Marocco, A, Ruggeri, F, Titone, L, Tozzi, A, Vitali Rosati, G, Zotti, C & Franco, E 2009, 'Monitoring the rate of hospitalization before rotavirus immunization in Italy utilizing ICD9-CM regional databases', Human Vaccines, vol. 5, no. 3, pp. 172-176. https://doi.org/10.4161/hv.5.3.6764
Marchetti, Federico ; Assael, Barouk ; Gabutti, Giovanni ; Guarino, Alfredo ; Luigi Lopalco, Pier ; Marocco, Alessia ; Ruggeri, Franco ; Titone, Lucina ; Tozzi, Alberto ; Vitali Rosati, Giovanni ; Zotti, Carla ; Franco, Elisabetta. / Monitoring the rate of hospitalization before rotavirus immunization in Italy utilizing ICD9-CM regional databases. In: Human Vaccines. 2009 ; Vol. 5, No. 3. pp. 172-176.
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AU - Assael, Barouk

AU - Gabutti, Giovanni

AU - Guarino, Alfredo

AU - Luigi Lopalco, Pier

AU - Marocco, Alessia

AU - Ruggeri, Franco

AU - Titone, Lucina

AU - Tozzi, Alberto

AU - Vitali Rosati, Giovanni

AU - Zotti, Carla

AU - Franco, Elisabetta

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N2 - Background: Recently, two Rotavirus (RV) vaccines were licensed in Italy, rendering RV illness a vaccine preventable disease. To assess the RV hospitalization rate in Italy, a study focused on the Regional hospital discharge forms (HDD) databases was carried out. Results: Regional HDD databases from Piemonte, Veneto, Friuli-Venezia-Giulia and Marche were analyzed. A total of 434,335 hospitalizations were counted in the study timeframe and 13,234 VE diagnoses (3% of hospitalizations) were collected. A total of 8546 RVE cases (2% of hospitalizations, 64% of all VE) were observed, of which 1.2% were primary diagnoses (PD) and 0.8% secondary diagnosis (SD). The RVE hospitalization peak (4.9%) was observed at the age of 1 year (4.5% in 7-12 months of age) with a median hospital stay of 4.4 days (s.d ± 4.2). Two deaths (out of 8546 RVE cases) were identified. Patients and methods: Regional HDD databases with the diagnosis of viral enteritis (VE) and RV enteritis (RVE) (ICD9-CM code 00861-69 and 008.8) in any position of the first 20 discharge diagnoses in children aged less or equal to 5 years between 2001 and 2005 were requested. Conclusion: Despite some limitations due to the HDD synthetic contents and low potential for clinical interpretation, the Regional HDD databases, including PD and SD, may be a useful tool for monitoring the clinical impact of RV vaccination introduction in Italy.

AB - Background: Recently, two Rotavirus (RV) vaccines were licensed in Italy, rendering RV illness a vaccine preventable disease. To assess the RV hospitalization rate in Italy, a study focused on the Regional hospital discharge forms (HDD) databases was carried out. Results: Regional HDD databases from Piemonte, Veneto, Friuli-Venezia-Giulia and Marche were analyzed. A total of 434,335 hospitalizations were counted in the study timeframe and 13,234 VE diagnoses (3% of hospitalizations) were collected. A total of 8546 RVE cases (2% of hospitalizations, 64% of all VE) were observed, of which 1.2% were primary diagnoses (PD) and 0.8% secondary diagnosis (SD). The RVE hospitalization peak (4.9%) was observed at the age of 1 year (4.5% in 7-12 months of age) with a median hospital stay of 4.4 days (s.d ± 4.2). Two deaths (out of 8546 RVE cases) were identified. Patients and methods: Regional HDD databases with the diagnosis of viral enteritis (VE) and RV enteritis (RVE) (ICD9-CM code 00861-69 and 008.8) in any position of the first 20 discharge diagnoses in children aged less or equal to 5 years between 2001 and 2005 were requested. Conclusion: Despite some limitations due to the HDD synthetic contents and low potential for clinical interpretation, the Regional HDD databases, including PD and SD, may be a useful tool for monitoring the clinical impact of RV vaccination introduction in Italy.

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