Monitoring treatment response in psoriasis: current perspectives on the clinical utility of reflectance confocal microscopy

Marina Agozzino, Cecilia Noal, Francesco Lacarrubba, Marco Ardigò

Research output: Contribution to journalReview article

Abstract

Reflectance confocal microscopy (RCM) evaluation of inflammatory skin diseases represents a relatively new technique that, during the past 5 years, has attracted increasing interest, with consequent progressive increment of publications in literature. The success of RCM is directly related to the high need for noninvasive techniques able to both reduce the number of skin biopsies and support clinical diagnosis and patient management. RCM helps to visualize microscopic descriptors of plaque psoriasis (PP) with good reproducibility between observers and a high grade of correspondence with histopathology. Several clinical tests are used for the therapeutic management of PP, but they are limited by subjective interpretation. Skin biopsy presents objective interpretation, but the procedure is invasive and not repeatable. RCM has been used not only for the evaluation of skin cancer or inflammatory skin diseases, but also for monitoring the efficacy of different treatments in PP. In this review, we present some examples of RCM applications in therapeutic psoriasis follow-up.

Original languageEnglish
Pages (from-to)27-34
Number of pages8
JournalPsoriasis (Auckland, N.Z.)
Volume7
DOIs
Publication statusPublished - Feb 20 2017

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