Monoamine acid metabolites and cerebrospinal fluid dynamics in normal pressure hydrocephalus: preliminary results

G. Maira, S. R. Bareggi, C. Di Rocco, G. Calderini, P. L. Morselli

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Abstract

Lumbar and ventricular CSF concentration of homovanillic acid (HVA) and 5 hydroxyindole acetic acid (5 HIAA) have been determined in 13 patients admitted to hospital for suspected normal pressure hydrocephalus. Low values of HVA in lumbar CSF were found in all patients with reduced CSF absorption and CSF flow inversion. The HVA lumbar concentration remained low after shunt procedure; it increased if obstruction of the shunt occurred. The ventricular CSF concentration of HVA was normal before surgery; it became higher, in 2 cases, after surgery. No important variations were found in the lumbar and ventricular CSF concentration of 5 HIAA. The possible mechanism and diagnostic value of these findings are discussed.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume38
Issue number2
Publication statusPublished - 1975

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ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

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