Monoamine involvement in the overeating caused by muscimol injection in the rat nucleus raphe dorsalis and the effects of d-fenfluramine and d-amphetamine

Franco Borsini, Caterina Bendotti, Barbara Przewlocka, Rosario Samanin

Research output: Contribution to journalArticlepeer-review

Abstract

Injections of 5,7-dihydroxytryptamine in the nucleus raphe dorsalis did not significantly modify the eating caused by muscimol (100 ng) injected in the same area of freely fed rats 11 days later. Eating caused by muscimol, like food intake in starved rats, was significantly reduced by phenoxybenzamine (5, 10 and 20 mg/kg i.p.). Penfluridol (2.5 and 5 mg/kg p.o.), a dopamine receptor blocker, markedly reduced muscimol-induced eating, but had no effect on the food intake of starved rats. d-Fenfluramine (2.5 mg/kg i.p.), a releaser of serotonin from nerve terminals, significantly reduced eating in muscimol-injected and starved animals whereas d-amphetamine 1.25 and 2.5 mg/kg i.p. only inhibited the food intake of starved rats. Eating elicited by muscimol injected in the nucleus raphe dorsalis appears to constitute a catecholamine-mediated model of hyperphagia selectively inhibited by agents which increase serotonin transmission.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalEuropean Journal of Pharmacology
Volume94
Issue number1-2
DOIs
Publication statusPublished - Oct 14 1983

Keywords

  • 5
  • 7-Dihydroxytryptamine
  • Catecholamine receptors
  • d-Amphetamine
  • d-Fenfluramine
  • Model of overeating
  • Muscimol
  • Nucleus dorsalis raphe

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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