Monoamine oxidase activity and distribution in marmoset brain: implications for MPTP toxicity

Jane Willoughby, Vivette Glover, Merton Sandler, Alberto Albanese, Peter Jenner, C. David Marsden

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

This study describes the histochemical localisation of monoamine oxidase (MAO) in marmoset brain. No MAO A staining was observed but MAO B was found in many areas, with medium intensity of staining in the substantia nigra, and high intensity staining in the striatum and nucleus accumbens, among other regions. The high activity in the nigrostriatal tract, compared with the rat, may partially explain the greater sensitivity of the marmoset to MPTP toxicity. As in the rat, high activity was present in the raphe nuclei. However, unlike the rat, no enrichment of MAO B was observed in blood vessels or ventricular linings.

Original languageEnglish
Pages (from-to)100-106
Number of pages7
JournalNeuroscience Letters
Volume90
Issue number1-2
DOIs
Publication statusPublished - Jul 19 1988

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Callithrix
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Monoamine Oxidase
Brain
Staining and Labeling
Raphe Nuclei
Nucleus Accumbens
Substantia Nigra
Blood Vessels

Keywords

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
  • Histochemistry
  • Marmoset
  • Monoamine oxidase
  • Nigrostriatal pathway
  • Parkinson's disease
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Monoamine oxidase activity and distribution in marmoset brain : implications for MPTP toxicity. / Willoughby, Jane; Glover, Vivette; Sandler, Merton; Albanese, Alberto; Jenner, Peter; Marsden, C. David.

In: Neuroscience Letters, Vol. 90, No. 1-2, 19.07.1988, p. 100-106.

Research output: Contribution to journalArticle

Willoughby, Jane ; Glover, Vivette ; Sandler, Merton ; Albanese, Alberto ; Jenner, Peter ; Marsden, C. David. / Monoamine oxidase activity and distribution in marmoset brain : implications for MPTP toxicity. In: Neuroscience Letters. 1988 ; Vol. 90, No. 1-2. pp. 100-106.
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