Abstract
Monoclonal antibodies have been obtained that recognize either the A or B chain of human urinary urokinase. These antibodies identify human urokinase-producing cells and the product of urokinase mRNA. Anti-urokinase monoclonal antibodies precipitate an ~54,000-dalton protein synthesized in vitro in a rabbit reticulocyte cell-free system. The pro-urokinase appears to be the precursor of both A and B chains of human urinary urokinase. Urokinase mRNA in human kidney constitutes only 0.1% or less of total poly(A)+ RNA.
Original language | English |
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Pages (from-to) | 110-114 |
Number of pages | 5 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 81 |
Issue number | 1 I |
Publication status | Published - 1984 |
ASJC Scopus subject areas
- Genetics
- General