Monoclonal antibody analysis of blood T-cell subsets in multiple sclerosis

M. Zaffaroni, D. Caputo, A. Ghezzi, S. Marforio, C. L. Cazzullo

Research output: Contribution to journalArticlepeer-review

Abstract

The present study deals with the characterization of peripheral blood T-cell subpopulations in multiple sclerosis (MS) patients during different stages of the disease. An indirect immunofluorescence assay was performed using monoclonal antibodies directed at lymphocyte surface antigens. Patients in exacerbation were found to have significantly (p <0.001) reduced OKT8+ (T-suppressor) cells and a high helper/suppressor ratio (p <0.001). Patients in remission showed a significant increase of suppressor T-cells compared to controls (p <0.02) and patients during relapse (p <0.001); H/S ratio was consequently low compared to acute MS (p <0.001) and controls (p <0.1). Patients with a progressive course showed an intermediate T-subset pattern. The results are discussed in the light of the most recent neuroimmunological approaches to MS.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalItalian Journal of Neurological Sciences
Volume5
Issue number1
DOIs
Publication statusPublished - Mar 1984

Keywords

  • monoclonal antibodies
  • Multiple sclerosis
  • T-lymphocytes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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