Monoclonal antibody analysis of blood T-cell subsets in multiple sclerosis

M. Zaffaroni; D. Caputo; A. Ghezzi; S. Marforio; C. L. Cazzullo

doi:10.1007/BF02043969

Monoclonal antibody analysis of blood T-cell subsets in multiple sclerosis

M. Zaffaroni, D. Caputo, A. Ghezzi, S. Marforio, C. L. Cazzullo

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

The present study deals with the characterization of peripheral blood T-cell subpopulations in multiple sclerosis (MS) patients during different stages of the disease. An indirect immunofluorescence assay was performed using monoclonal antibodies directed at lymphocyte surface antigens. Patients in exacerbation were found to have significantly (p <0.001) reduced OKT₈+ (T-suppressor) cells and a high helper/suppressor ratio (p <0.001). Patients in remission showed a significant increase of suppressor T-cells compared to controls (p <0.02) and patients during relapse (p <0.001); H/S ratio was consequently low compared to acute MS (p <0.001) and controls (p <0.1). Patients with a progressive course showed an intermediate T-subset pattern. The results are discussed in the light of the most recent neuroimmunological approaches to MS.

Original language	English
Pages (from-to)	45-50
Number of pages	6
Journal	Italian Journal of Neurological Sciences
Volume	5
Issue number	1
DOIs	https://doi.org/10.1007/BF02043969
Publication status	Published - Mar 1984

Keywords

monoclonal antibodies
Multiple sclerosis
T-lymphocytes

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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AU - Zaffaroni, M.

AU - Caputo, D.

AU - Ghezzi, A.

AU - Marforio, S.

AU - Cazzullo, C. L.

PY - 1984/3

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N2 - The present study deals with the characterization of peripheral blood T-cell subpopulations in multiple sclerosis (MS) patients during different stages of the disease. An indirect immunofluorescence assay was performed using monoclonal antibodies directed at lymphocyte surface antigens. Patients in exacerbation were found to have significantly (p <0.001) reduced OKT8+ (T-suppressor) cells and a high helper/suppressor ratio (p <0.001). Patients in remission showed a significant increase of suppressor T-cells compared to controls (p <0.02) and patients during relapse (p <0.001); H/S ratio was consequently low compared to acute MS (p <0.001) and controls (p <0.1). Patients with a progressive course showed an intermediate T-subset pattern. The results are discussed in the light of the most recent neuroimmunological approaches to MS.

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Monoclonal antibody analysis of blood T-cell subsets in multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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