Abstract
The present study deals with the characterization of peripheral blood T-cell subpopulations in multiple sclerosis (MS) patients during different stages of the disease. An indirect immunofluorescence assay was performed using monoclonal antibodies directed at lymphocyte surface antigens. Patients in exacerbation were found to have significantly (p <0.001) reduced OKT8+ (T-suppressor) cells and a high helper/suppressor ratio (p <0.001). Patients in remission showed a significant increase of suppressor T-cells compared to controls (p <0.02) and patients during relapse (p <0.001); H/S ratio was consequently low compared to acute MS (p <0.001) and controls (p <0.1). Patients with a progressive course showed an intermediate T-subset pattern. The results are discussed in the light of the most recent neuroimmunological approaches to MS.
Original language | English |
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Pages (from-to) | 45-50 |
Number of pages | 6 |
Journal | Italian Journal of Neurological Sciences |
Volume | 5 |
Issue number | 1 |
DOIs | |
Publication status | Published - Mar 1984 |
Keywords
- monoclonal antibodies
- Multiple sclerosis
- T-lymphocytes
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology