Monoclonal antibody assessment of lymphocyte subpopulations in adult rheumatoid arthritis in relation to stage and treatment

A. Pappalardo, M. Musso, L. Salli, P. Di Prima, V. Accurso, E. Caradonna

Research output: Contribution to journalArticle

Abstract

Twenty patients with various stages of RA were examined. They included: 1) 7 cases in Steinbroker stage 1 (onset); 2) 13 cases in Steinbroker stage 2-3 (chronic). The group was divided into 16 treated and 4 untreated cases. Monoclonal antibodies were used to assay T3, T4, T8 and the T4/T8 ratio and the results were compared with those in a control group. The results showed a T8 deficit and a consequent change in the T4/T8 ratio in untreated subjects with 'onset' RA. The immune situation of the chronic and treated cases was very similar to that in the control group probably as a result of treatment.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalMinerva Medica
Volume79
Issue number3
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Medicine(all)

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