Monoclonal B-cell lymphocytosis (MBL)

Biology, natural history and clinical management

T. D. Shanafelt, P. Ghia, M. C. Lanasa, O. Landgren, A. C. Rawstron

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Chronic lymphocytic leukemia (CLL) and the other low-grade non-Hodgkin lymphomas are among the most common lymphoid malignancies. Recent studies suggest that more than 4% of the general population over age 40 harbor a population of clonal B cells with the phenotype of either CLL or another B-cell malignancy, a condition now designated monoclonal B-cell lymphocytosis (MBL). Although all cases of CLL appear to be preceded by MBL, the majority of individuals with MBL will not develop a hematologic malignancy. The biologic characteristics and clinical implications of MBL appear to differ based on whether it is identified during the diagnostic evaluation of lymphocytosis or incidentally discovered through screening of individuals with normal lymphocyte counts as part of research studies using highly sensitive detection methods. In this paper, we provide a state of the art review on the prevalence, nomenclature, biology, natural history and clinical management of MBL.

Original languageEnglish
Pages (from-to)512-520
Number of pages9
JournalLeukemia
Volume24
Issue number3
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Lymphocytosis
Natural History
Cell Biology
B-Lymphocytes
B-Cell Chronic Lymphocytic Leukemia
Non-Hodgkin's Lymphoma
Lymphocyte Count
Hematologic Neoplasms
Terminology
Population
Neoplasms
Phenotype
Research

Keywords

  • Biology
  • Chronic lymphocytic leukemia (CLL)
  • Management
  • Monoclonal B-cell lymphocytosis (MBL)
  • Non-Hodgkin lymphoma
  • Prognosis

ASJC Scopus subject areas

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine

Cite this

Monoclonal B-cell lymphocytosis (MBL) : Biology, natural history and clinical management. / Shanafelt, T. D.; Ghia, P.; Lanasa, M. C.; Landgren, O.; Rawstron, A. C.

In: Leukemia, Vol. 24, No. 3, 03.2010, p. 512-520.

Research output: Contribution to journalArticle

Shanafelt, TD, Ghia, P, Lanasa, MC, Landgren, O & Rawstron, AC 2010, 'Monoclonal B-cell lymphocytosis (MBL): Biology, natural history and clinical management', Leukemia, vol. 24, no. 3, pp. 512-520. https://doi.org/10.1038/leu.2009.287
Shanafelt, T. D. ; Ghia, P. ; Lanasa, M. C. ; Landgren, O. ; Rawstron, A. C. / Monoclonal B-cell lymphocytosis (MBL) : Biology, natural history and clinical management. In: Leukemia. 2010 ; Vol. 24, No. 3. pp. 512-520.
@article{86105a9ddf55497cbb87dff08c2edad2,
title = "Monoclonal B-cell lymphocytosis (MBL): Biology, natural history and clinical management",
abstract = "Chronic lymphocytic leukemia (CLL) and the other low-grade non-Hodgkin lymphomas are among the most common lymphoid malignancies. Recent studies suggest that more than 4{\%} of the general population over age 40 harbor a population of clonal B cells with the phenotype of either CLL or another B-cell malignancy, a condition now designated monoclonal B-cell lymphocytosis (MBL). Although all cases of CLL appear to be preceded by MBL, the majority of individuals with MBL will not develop a hematologic malignancy. The biologic characteristics and clinical implications of MBL appear to differ based on whether it is identified during the diagnostic evaluation of lymphocytosis or incidentally discovered through screening of individuals with normal lymphocyte counts as part of research studies using highly sensitive detection methods. In this paper, we provide a state of the art review on the prevalence, nomenclature, biology, natural history and clinical management of MBL.",
keywords = "Biology, Chronic lymphocytic leukemia (CLL), Management, Monoclonal B-cell lymphocytosis (MBL), Non-Hodgkin lymphoma, Prognosis",
author = "Shanafelt, {T. D.} and P. Ghia and Lanasa, {M. C.} and O. Landgren and Rawstron, {A. C.}",
year = "2010",
month = "3",
doi = "10.1038/leu.2009.287",
language = "English",
volume = "24",
pages = "512--520",
journal = "Leukemia",
issn = "0887-6924",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Monoclonal B-cell lymphocytosis (MBL)

T2 - Biology, natural history and clinical management

AU - Shanafelt, T. D.

AU - Ghia, P.

AU - Lanasa, M. C.

AU - Landgren, O.

AU - Rawstron, A. C.

PY - 2010/3

Y1 - 2010/3

N2 - Chronic lymphocytic leukemia (CLL) and the other low-grade non-Hodgkin lymphomas are among the most common lymphoid malignancies. Recent studies suggest that more than 4% of the general population over age 40 harbor a population of clonal B cells with the phenotype of either CLL or another B-cell malignancy, a condition now designated monoclonal B-cell lymphocytosis (MBL). Although all cases of CLL appear to be preceded by MBL, the majority of individuals with MBL will not develop a hematologic malignancy. The biologic characteristics and clinical implications of MBL appear to differ based on whether it is identified during the diagnostic evaluation of lymphocytosis or incidentally discovered through screening of individuals with normal lymphocyte counts as part of research studies using highly sensitive detection methods. In this paper, we provide a state of the art review on the prevalence, nomenclature, biology, natural history and clinical management of MBL.

AB - Chronic lymphocytic leukemia (CLL) and the other low-grade non-Hodgkin lymphomas are among the most common lymphoid malignancies. Recent studies suggest that more than 4% of the general population over age 40 harbor a population of clonal B cells with the phenotype of either CLL or another B-cell malignancy, a condition now designated monoclonal B-cell lymphocytosis (MBL). Although all cases of CLL appear to be preceded by MBL, the majority of individuals with MBL will not develop a hematologic malignancy. The biologic characteristics and clinical implications of MBL appear to differ based on whether it is identified during the diagnostic evaluation of lymphocytosis or incidentally discovered through screening of individuals with normal lymphocyte counts as part of research studies using highly sensitive detection methods. In this paper, we provide a state of the art review on the prevalence, nomenclature, biology, natural history and clinical management of MBL.

KW - Biology

KW - Chronic lymphocytic leukemia (CLL)

KW - Management

KW - Monoclonal B-cell lymphocytosis (MBL)

KW - Non-Hodgkin lymphoma

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=77949422979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949422979&partnerID=8YFLogxK

U2 - 10.1038/leu.2009.287

DO - 10.1038/leu.2009.287

M3 - Article

VL - 24

SP - 512

EP - 520

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 3

ER -