Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia

A. Corbingi; I. Innocenti; A. Tomasso; R. Pasquale; A. Visentin; M. Varettoni; E. Flospergher; F. Autore; F. Morelli; L. Trentin; G. Reda; D.G. Efremov; L. Laurenti

doi:10.1111/bjh.16975

Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia

A. Corbingi, I. Innocenti, A. Tomasso, R. Pasquale, A. Visentin, M. Varettoni, E. Flospergher, F. Autore, F. Morelli, L. Trentin, G. Reda, D.G. Efremov, L. Laurenti

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Abstract

The relationship between chronic lymphocytic leukaemia (CLL) and qualitative/quantitative gammaglobulin abnormalities is well established. Nevertheless, in order to better understand this kind of connection, we examined 1505 patients with CLL and divided them into four subgroups on the basis of immunoglobulin (Ig) aberrations at diagnosis. A total of 73 (4·8%), 149 (10%), 200 (13·2%) and 1083 (72%) patients were identified with IgM monoclonal gammopathy (IgM/CLL), IgG monoclonal gammopathy (IgG/CLL), hypogammaglobulinaemia (hypo-γ) and normal Ig levels (γ-normal) respectively. IgM paraprotein was significantly associated with a more advanced Binet/Rai stage and del(17p)/TP53 mutation, while IgG abnormalities correlated with a higher occurrence of trisomy 12. Patients with any type of Ig abnormality had shorter treatment-free survival (TFS) but no significant impact affecting overall survival (OS) compared to those with normal Ig levels.

Original language	English
Pages (from-to)	901-908
Number of pages	8
Journal	British Journal of Haematology
Volume	190
Issue number	6
DOIs	https://doi.org/10.1111/bjh.16975
Publication status	Published - 2020

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Corbingi, A., Innocenti, I., Tomasso, A., Pasquale, R., Visentin, A., Varettoni, M., Flospergher, E., Autore, F., Morelli, F., Trentin, L., Reda, G., Efremov, D. G., & Laurenti, L. (2020). Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia. British Journal of Haematology, 190(6), 901-908. https://doi.org/10.1111/bjh.16975

Corbingi, A, Innocenti, I, Tomasso, A, Pasquale, R, Visentin, A, Varettoni, M, Flospergher, E, Autore, F, Morelli, F, Trentin, L, Reda, G, Efremov, DG & Laurenti, L 2020, 'Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia', British Journal of Haematology, vol. 190, no. 6, pp. 901-908. https://doi.org/10.1111/bjh.16975

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title = "Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia",

abstract = "The relationship between chronic lymphocytic leukaemia (CLL) and qualitative/quantitative gammaglobulin abnormalities is well established. Nevertheless, in order to better understand this kind of connection, we examined 1505 patients with CLL and divided them into four subgroups on the basis of immunoglobulin (Ig) aberrations at diagnosis. A total of 73 (4·8%), 149 (10%), 200 (13·2%) and 1083 (72%) patients were identified with IgM monoclonal gammopathy (IgM/CLL), IgG monoclonal gammopathy (IgG/CLL), hypogammaglobulinaemia (hypo-γ) and normal Ig levels (γ-normal) respectively. IgM paraprotein was significantly associated with a more advanced Binet/Rai stage and del(17p)/TP53 mutation, while IgG abnormalities correlated with a higher occurrence of trisomy 12. Patients with any type of Ig abnormality had shorter treatment-free survival (TFS) but no significant impact affecting overall survival (OS) compared to those with normal Ig levels.",

author = "A. Corbingi and I. Innocenti and A. Tomasso and R. Pasquale and A. Visentin and M. Varettoni and E. Flospergher and F. Autore and F. Morelli and L. Trentin and G. Reda and D.G. Efremov and L. Laurenti",

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AU - Corbingi, A.

AU - Innocenti, I.

AU - Tomasso, A.

AU - Pasquale, R.

AU - Visentin, A.

AU - Varettoni, M.

AU - Flospergher, E.

AU - Autore, F.

AU - Morelli, F.

AU - Trentin, L.

AU - Reda, G.

AU - Efremov, D.G.

AU - Laurenti, L.

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N2 - The relationship between chronic lymphocytic leukaemia (CLL) and qualitative/quantitative gammaglobulin abnormalities is well established. Nevertheless, in order to better understand this kind of connection, we examined 1505 patients with CLL and divided them into four subgroups on the basis of immunoglobulin (Ig) aberrations at diagnosis. A total of 73 (4·8%), 149 (10%), 200 (13·2%) and 1083 (72%) patients were identified with IgM monoclonal gammopathy (IgM/CLL), IgG monoclonal gammopathy (IgG/CLL), hypogammaglobulinaemia (hypo-γ) and normal Ig levels (γ-normal) respectively. IgM paraprotein was significantly associated with a more advanced Binet/Rai stage and del(17p)/TP53 mutation, while IgG abnormalities correlated with a higher occurrence of trisomy 12. Patients with any type of Ig abnormality had shorter treatment-free survival (TFS) but no significant impact affecting overall survival (OS) compared to those with normal Ig levels.

AB - The relationship between chronic lymphocytic leukaemia (CLL) and qualitative/quantitative gammaglobulin abnormalities is well established. Nevertheless, in order to better understand this kind of connection, we examined 1505 patients with CLL and divided them into four subgroups on the basis of immunoglobulin (Ig) aberrations at diagnosis. A total of 73 (4·8%), 149 (10%), 200 (13·2%) and 1083 (72%) patients were identified with IgM monoclonal gammopathy (IgM/CLL), IgG monoclonal gammopathy (IgG/CLL), hypogammaglobulinaemia (hypo-γ) and normal Ig levels (γ-normal) respectively. IgM paraprotein was significantly associated with a more advanced Binet/Rai stage and del(17p)/TP53 mutation, while IgG abnormalities correlated with a higher occurrence of trisomy 12. Patients with any type of Ig abnormality had shorter treatment-free survival (TFS) but no significant impact affecting overall survival (OS) compared to those with normal Ig levels.

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DO - 10.1111/bjh.16975

M3 - Article

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JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 6

ER -

Monoclonal gammopathy and serum immunoglobulin levels as prognostic factors in chronic lymphocytic leukaemia

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