Monoclonal gammopathy of undetermined significance: A new proposal of workup

Silvia Mangiacavalli, Federica Cocito, Lara Pochintesta, Cristiana Pascutto, Virginia Ferretti, Marzia Varettoni, Patrizia Zappasodi, Alessandra Pompa, Benedetta Landini, Mario Cazzola, Alessandro Corso

Research output: Contribution to journalArticle


Objective: Diagnostic criteria for monoclonal gammopathy of undetermined significance (MGUS) require quantification of bone marrow plasma cells (BMPCs) and skeletal survey to discriminate between MGUS and multiple myeloma (MM). By contrast, recent published guidelines suggest that these procedures could be avoided in the presence of serum monoclonal spike (M-spike) of small amount (≤1.5 g/dL). Aim of this study is to better quantify the risk of missing a diagnosis of MM, not performing bone marrow aspirate and skeletal survey in patients with M-spike ≤ 1.5 g/dL asymptomatic for bone pain. Methods: We reviewed data of 2282 patients consecutively observed from January 1974 to December 2010 in our single hematology department. We considered eligible for this study 1271 patients with grade

Original languageEnglish
Pages (from-to)356-360
Number of pages5
JournalEuropean Journal of Haematology
Issue number4
Publication statusPublished - Oct 2013


  • Diagnostic workup
  • Monoclonal gammopathy of undetermined significance
  • Myeloma

ASJC Scopus subject areas

  • Hematology

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