Monoclonal IgM-associated demyelinating peripheral neuropathy: An expression of monoclonal autoimmunity

A. M. Marmont, G. L. Mancardi, M. Tabaton, M. Siccardi, L. Grassia, A. Schenone, M. Repetto

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A chronic sensimotor polyneuropathy is well known to occur in association to IgM monoclonal disease of undetermined significance. The monoclonal immunoglobulins bind specifically to the myelin sheats of peripheral nerves and have probably pathogenetic significance. In the present paper we report two cases of monoclonal IgM-associated chronic sensimotor neuropathy. Sural nerve biopsy immunofluorescent studies showed a specific IgM-K reactivity along the myelin sheaths. Indirect immunofluorescence using frog sciatic nerve and patient's 2 serum was also positive with IgM-K reactivity. Transmission electron microscopic studies showed the characteristic separation of the dense intraperiod lines of the myelin sheath. In chronic sensimotor polyneuropathy associated to IgM disease a primary transformation of a B clonogenic cell synthetizing natural antibodies against the myelin associated glycoprotein (MAG) may be the original event. The definition of 'monoclonal autoimmunity' seems best to indicate this group of autoimmune conditions.

Original languageEnglish
Pages (from-to)471-476
Number of pages6
Issue number6
Publication statusPublished - Dec 1 1985

ASJC Scopus subject areas

  • Hematology


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