Monoclonals and allergy. A review, with experimental contribution.

A. Albertini, E. Antoniazzi, S. Archetti, G. Bugari, R. Cabula, E. Ghezzi, S. Ghielmi, G. Sacchi, G. C. Tassi, S. Tombesi

Research output: Contribution to journalArticlepeer-review

Abstract

The role of monoclonal antibodies in allergy has been explored. First the status of art of monoclonal research in general is reviewed, by outlining a monoclonals identikit and the relevant technologies employed for their development. The attention is then focused on the present impact of monoclonals in the allergological field, first considering a general outline, and then the important steps of standardization of monoclonal antibodies. A comprehensive hint is made concerning the monitoring of immunotherapy, with future extrapolations on developing anti-idiotype vaccines, of which same examples can already be found in the infectious field, thus leaving the way open in allergy as well. A second section deals with the experimental contribution of the Authors, with the description of the preparation of the allergenic extracts of D.F., with details of the relevant steps (rabbit immunization; extract characterization; techniques used for monoclonal screening and characterization). The results obtained are discussed in relation to the techniques employed, weighing the reciprocal advantages and drawbacks.

Original languageEnglish
Pages (from-to)1-35
Number of pages35
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume67
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Immunology

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