Monocyclic analogues of the μ-opioid agonist 3,8-diazabicyclo [3.2.1]octanes: Synthesis, modeling, and activity

Daniela Barlocco, Stefania Villa, Walter Fratta, Paola Fadda, Diego Colombo, Lucio Toma

Research output: Contribution to journalArticlepeer-review

Abstract

Several monocyclic derivatives structurally related to the μ-opioid agonist 3-cinnamyl-8 propionyl-3,8-diazabicyclo[3.2. 1]octane have been synthesized and tested in binding studies using the μ-selective 3H-DAMGO as ligand. Modeling studies have been performed on the same compounds in order to explain the observed lack of affinity towards μ-opioid receptors.

Original languageEnglish
Pages (from-to)11547-11556
Number of pages10
JournalTetrahedron
Volume51
Issue number42
DOIs
Publication statusPublished - Oct 16 1995

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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