Abstract
Several monocyclic derivatives structurally related to the μ-opioid agonist 3-cinnamyl-8 propionyl-3,8-diazabicyclo[3.2. 1]octane have been synthesized and tested in binding studies using the μ-selective 3H-DAMGO as ligand. Modeling studies have been performed on the same compounds in order to explain the observed lack of affinity towards μ-opioid receptors.
Original language | English |
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Pages (from-to) | 11547-11556 |
Number of pages | 10 |
Journal | Tetrahedron |
Volume | 51 |
Issue number | 42 |
DOIs | |
Publication status | Published - Oct 16 1995 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery