Monocyte chemoattractant protein 1: A possible link between visceral adipose tissue-associated inflammation and subclinical echocardiographic abnormalities in uncomplicated obesity

Alexis E. Malavazos, Emanuele Cereda, Lelio Morricone, Calin Coman, Massimiliano M. Corsi, Bruno Ambrosi

Research output: Contribution to journalArticle

Abstract

Objective: Obesity can be considered a state of chronic, low-grade inflammation. Particularly, visceral adipose tissue (VAT) seems to be an active compartment in pro-inflammatory molecule secretion. Adipocytes and VAT are able to produce large amounts of monocyte chemoattractant protein 1 (MCP-1), a chemokine directly involved in ventricular remodeling. Design: In this study, the possible existence of a correlation between MCP-1, abdominal fat accumulation and echocardiographic abnormalities in uncomplicated obesity was investigated. Methods: Echocardiographic parameters, MCP-1 and C-reactive protein (CRP) levels were assessed in 27 normotensive obese women of fertile age (body mass index 43.5±4.8 kg/m2, mean±S.D.) and 15 normal weight women. Visceral fat (VAT) in the obese group was assessed by computed tomography. Results: Obese patients had higher MCP-1 (P <0.0001) and CRP (P <0.0001) levels than controls. MCP-1 levels were correlated with VAT area (r=0.57, P <0.0001), CRP (P <0.0001), left ventricular mass (LVM) (P <0.02), LVM indexed for height (P <0.03), end-diastolic posterior wall (P <0.005), relative wall thickness (P <0.01), early diastolic filling wave velocity (P <0.01), isovolumetric relaxation time (P <0.001) and deceleration time (P <0,01). Obese patients with greater amounts of VAT (> 130 cm2) presented higher MCP-1 (P <0.0001) and CRP levels (P <0.04) than those with a lower degree of abdominal adiposity. Conclusions: MCP-1 levels and visceral adipose tissue seem to be associated with some morphological and functional echocardiographic abnormalities and support a role for visceral fat in predisposing the subject to cardiac dysfunction, possibly through a low-grade state of inflammation.

Original languageEnglish
Pages (from-to)871-877
Number of pages7
JournalEuropean Journal of Endocrinology
Volume153
Issue number6
DOIs
Publication statusPublished - Dec 2005

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Intra-Abdominal Fat
Chemokine CCL2
Obesity
Inflammation
C-Reactive Protein
Abdominal Fat
Ventricular Remodeling
Adiposity
Protein C
Chemokines
Adipocytes
Body Mass Index
Tomography
Weights and Measures

ASJC Scopus subject areas

  • Endocrinology

Cite this

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title = "Monocyte chemoattractant protein 1: A possible link between visceral adipose tissue-associated inflammation and subclinical echocardiographic abnormalities in uncomplicated obesity",
abstract = "Objective: Obesity can be considered a state of chronic, low-grade inflammation. Particularly, visceral adipose tissue (VAT) seems to be an active compartment in pro-inflammatory molecule secretion. Adipocytes and VAT are able to produce large amounts of monocyte chemoattractant protein 1 (MCP-1), a chemokine directly involved in ventricular remodeling. Design: In this study, the possible existence of a correlation between MCP-1, abdominal fat accumulation and echocardiographic abnormalities in uncomplicated obesity was investigated. Methods: Echocardiographic parameters, MCP-1 and C-reactive protein (CRP) levels were assessed in 27 normotensive obese women of fertile age (body mass index 43.5±4.8 kg/m2, mean±S.D.) and 15 normal weight women. Visceral fat (VAT) in the obese group was assessed by computed tomography. Results: Obese patients had higher MCP-1 (P <0.0001) and CRP (P <0.0001) levels than controls. MCP-1 levels were correlated with VAT area (r=0.57, P <0.0001), CRP (P <0.0001), left ventricular mass (LVM) (P <0.02), LVM indexed for height (P <0.03), end-diastolic posterior wall (P <0.005), relative wall thickness (P <0.01), early diastolic filling wave velocity (P <0.01), isovolumetric relaxation time (P <0.001) and deceleration time (P <0,01). Obese patients with greater amounts of VAT (> 130 cm2) presented higher MCP-1 (P <0.0001) and CRP levels (P <0.04) than those with a lower degree of abdominal adiposity. Conclusions: MCP-1 levels and visceral adipose tissue seem to be associated with some morphological and functional echocardiographic abnormalities and support a role for visceral fat in predisposing the subject to cardiac dysfunction, possibly through a low-grade state of inflammation.",
author = "Malavazos, {Alexis E.} and Emanuele Cereda and Lelio Morricone and Calin Coman and Corsi, {Massimiliano M.} and Bruno Ambrosi",
year = "2005",
month = "12",
doi = "10.1530/eje.1.02033",
language = "English",
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pages = "871--877",
journal = "European Journal of Endocrinology",
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TY - JOUR

T1 - Monocyte chemoattractant protein 1

T2 - A possible link between visceral adipose tissue-associated inflammation and subclinical echocardiographic abnormalities in uncomplicated obesity

AU - Malavazos, Alexis E.

AU - Cereda, Emanuele

AU - Morricone, Lelio

AU - Coman, Calin

AU - Corsi, Massimiliano M.

AU - Ambrosi, Bruno

PY - 2005/12

Y1 - 2005/12

N2 - Objective: Obesity can be considered a state of chronic, low-grade inflammation. Particularly, visceral adipose tissue (VAT) seems to be an active compartment in pro-inflammatory molecule secretion. Adipocytes and VAT are able to produce large amounts of monocyte chemoattractant protein 1 (MCP-1), a chemokine directly involved in ventricular remodeling. Design: In this study, the possible existence of a correlation between MCP-1, abdominal fat accumulation and echocardiographic abnormalities in uncomplicated obesity was investigated. Methods: Echocardiographic parameters, MCP-1 and C-reactive protein (CRP) levels were assessed in 27 normotensive obese women of fertile age (body mass index 43.5±4.8 kg/m2, mean±S.D.) and 15 normal weight women. Visceral fat (VAT) in the obese group was assessed by computed tomography. Results: Obese patients had higher MCP-1 (P <0.0001) and CRP (P <0.0001) levels than controls. MCP-1 levels were correlated with VAT area (r=0.57, P <0.0001), CRP (P <0.0001), left ventricular mass (LVM) (P <0.02), LVM indexed for height (P <0.03), end-diastolic posterior wall (P <0.005), relative wall thickness (P <0.01), early diastolic filling wave velocity (P <0.01), isovolumetric relaxation time (P <0.001) and deceleration time (P <0,01). Obese patients with greater amounts of VAT (> 130 cm2) presented higher MCP-1 (P <0.0001) and CRP levels (P <0.04) than those with a lower degree of abdominal adiposity. Conclusions: MCP-1 levels and visceral adipose tissue seem to be associated with some morphological and functional echocardiographic abnormalities and support a role for visceral fat in predisposing the subject to cardiac dysfunction, possibly through a low-grade state of inflammation.

AB - Objective: Obesity can be considered a state of chronic, low-grade inflammation. Particularly, visceral adipose tissue (VAT) seems to be an active compartment in pro-inflammatory molecule secretion. Adipocytes and VAT are able to produce large amounts of monocyte chemoattractant protein 1 (MCP-1), a chemokine directly involved in ventricular remodeling. Design: In this study, the possible existence of a correlation between MCP-1, abdominal fat accumulation and echocardiographic abnormalities in uncomplicated obesity was investigated. Methods: Echocardiographic parameters, MCP-1 and C-reactive protein (CRP) levels were assessed in 27 normotensive obese women of fertile age (body mass index 43.5±4.8 kg/m2, mean±S.D.) and 15 normal weight women. Visceral fat (VAT) in the obese group was assessed by computed tomography. Results: Obese patients had higher MCP-1 (P <0.0001) and CRP (P <0.0001) levels than controls. MCP-1 levels were correlated with VAT area (r=0.57, P <0.0001), CRP (P <0.0001), left ventricular mass (LVM) (P <0.02), LVM indexed for height (P <0.03), end-diastolic posterior wall (P <0.005), relative wall thickness (P <0.01), early diastolic filling wave velocity (P <0.01), isovolumetric relaxation time (P <0.001) and deceleration time (P <0,01). Obese patients with greater amounts of VAT (> 130 cm2) presented higher MCP-1 (P <0.0001) and CRP levels (P <0.04) than those with a lower degree of abdominal adiposity. Conclusions: MCP-1 levels and visceral adipose tissue seem to be associated with some morphological and functional echocardiographic abnormalities and support a role for visceral fat in predisposing the subject to cardiac dysfunction, possibly through a low-grade state of inflammation.

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