Monocyte chemotactic protein-1 in the regulation of monocyte recruitment

A. Mantovani, B. Bottazzi, F. Colotta, G. Peri, P. Allavena, Gang Dong Quiang Gang Dong, A. Vecchi, S. Sozzani

Research output: Contribution to journalArticle

Abstract

Macrophages are a major component of the lymphoreticular infiltrate of tumors. Tumor-derived cytokines play an important role in the regulation of the recruitment and function of tumor-associated macrophages (TAM), TAM have pleiotropic function that influence various aspects of the immunobiology of neoplastic tissues including vascularization, stroma formation and dissolution, and growth rate. These cells, strategically located at the interface between tumor and host, have the potential to destroy neoplastic tissues and hence are a target for therapeutic intervention. Recent clinical results in ovarian cancer encourage this line.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalRegional Immunology
Volume6
Issue number5-6
Publication statusPublished - 1995

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Chemokine CCL2
Monocytes
Macrophages
Neoplasms
Ovarian Neoplasms
Cytokines
Growth

ASJC Scopus subject areas

  • Immunology

Cite this

Monocyte chemotactic protein-1 in the regulation of monocyte recruitment. / Mantovani, A.; Bottazzi, B.; Colotta, F.; Peri, G.; Allavena, P.; Quiang Gang Dong, Gang Dong; Vecchi, A.; Sozzani, S.

In: Regional Immunology, Vol. 6, No. 5-6, 1995, p. 445-448.

Research output: Contribution to journalArticle

Mantovani, A, Bottazzi, B, Colotta, F, Peri, G, Allavena, P, Quiang Gang Dong, GD, Vecchi, A & Sozzani, S 1995, 'Monocyte chemotactic protein-1 in the regulation of monocyte recruitment', Regional Immunology, vol. 6, no. 5-6, pp. 445-448.
Mantovani, A. ; Bottazzi, B. ; Colotta, F. ; Peri, G. ; Allavena, P. ; Quiang Gang Dong, Gang Dong ; Vecchi, A. ; Sozzani, S. / Monocyte chemotactic protein-1 in the regulation of monocyte recruitment. In: Regional Immunology. 1995 ; Vol. 6, No. 5-6. pp. 445-448.
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