Monocyte count at diagnosis is a prognostic parameter in diffuse large B-cell lymphoma

Results from a large multicenter study involving 1191 patients in the pre- and post-rituximab era

Tamar Tadmor, Alessia Bari, Stefano Sacchi, Luigi Marcheselli, Eliana Valentina Liardo, Irit Avivi, Noam Benyamini, Dina Attias, Samantha Pozzi, Maria Christina Cox, Luca Baldini, Maura Brugiatelli, Massimo Federico, Aaron Polliack

Research output: Contribution to journalArticle

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Abstract

In this study we assessed the prognostic significance of absolute monocyte count and selected the best cut-off value at diagnosis in a large cohort of patients with diffuse large B-cell lymphoma. Data were retrieved for therapy-naïve patients with diffuse large B-cell lymphoma followed in Israel and Italy during 1993-2010. A final cohort of 1017 patients was analyzed with a median follow up of 48 months and a 5-year overall survival rate of 68%. The best absolute monocyte count cut-off level was 630/mm3 and the 5-year overall survival for patients with counts below this cut-off was 71%, whereas it was 59% for those with a count >630 mm3 (P=0.0002). Of the 1017 patients, 521 (51%) were treated with chemo-immunotherapy, and in this cohort, using multivariate analysis, elevated monocyte count retained a negative prognostic value even when adjusted for International Prognostic Index (HR1.54, P=0.009). This large study shows that a simple parameter such as absolute monocyte count (>630/mm3) can easily be used routinely in the evaluation of newly diagnosed diffuse large B-cell lymphoma to identify high-risk patients with a worse survival in the rituximab era.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalHaematologica
Volume99
Issue number1
DOIs
Publication statusPublished - Jan 1 2014

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Lymphoma, Large B-Cell, Diffuse
Multicenter Studies
Monocytes
Survival
Israel
Immunotherapy
Italy
Rituximab
Multivariate Analysis
Survival Rate

ASJC Scopus subject areas

  • Hematology

Cite this

Monocyte count at diagnosis is a prognostic parameter in diffuse large B-cell lymphoma : Results from a large multicenter study involving 1191 patients in the pre- and post-rituximab era. / Tadmor, Tamar; Bari, Alessia; Sacchi, Stefano; Marcheselli, Luigi; Liardo, Eliana Valentina; Avivi, Irit; Benyamini, Noam; Attias, Dina; Pozzi, Samantha; Cox, Maria Christina; Baldini, Luca; Brugiatelli, Maura; Federico, Massimo; Polliack, Aaron.

In: Haematologica, Vol. 99, No. 1, 01.01.2014, p. 125-130.

Research output: Contribution to journalArticle

Tadmor, T, Bari, A, Sacchi, S, Marcheselli, L, Liardo, EV, Avivi, I, Benyamini, N, Attias, D, Pozzi, S, Cox, MC, Baldini, L, Brugiatelli, M, Federico, M & Polliack, A 2014, 'Monocyte count at diagnosis is a prognostic parameter in diffuse large B-cell lymphoma: Results from a large multicenter study involving 1191 patients in the pre- and post-rituximab era', Haematologica, vol. 99, no. 1, pp. 125-130. https://doi.org/10.3324/haematol.2013.088161
Tadmor, Tamar ; Bari, Alessia ; Sacchi, Stefano ; Marcheselli, Luigi ; Liardo, Eliana Valentina ; Avivi, Irit ; Benyamini, Noam ; Attias, Dina ; Pozzi, Samantha ; Cox, Maria Christina ; Baldini, Luca ; Brugiatelli, Maura ; Federico, Massimo ; Polliack, Aaron. / Monocyte count at diagnosis is a prognostic parameter in diffuse large B-cell lymphoma : Results from a large multicenter study involving 1191 patients in the pre- and post-rituximab era. In: Haematologica. 2014 ; Vol. 99, No. 1. pp. 125-130.
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