Abstract
The pathogenesis of HIV infection and the definition of the cell types target of HIV is the crucial background for the improvement of the therapeutic strategies against HIV infection. Monocyte-macrophages (M/M) are easily infected by HIV, and play a crucial role in the maintenance and the progression of HIV-related disease; HIV infection of M/M is the principal cause of HIV-related 'dementia complex'. Thus it is crucial that drugs used in the therapy of HIV infection are active against HIV replicating in cells of M/M lineage. In this paper the interaction between HIV and M/M is analyzed and the characteristics of viral replication in these cells, and the in vitro antiviral activity of several drugs in M/M are discussed. These data suggest that patients should be treated with drugs, that inhibit HIV also in M/M and, consequently, are able to block the clinical manifestations related to M/M infection, such as 'dementia complex'.
| Original language | Italian |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Medicina - Rivista della Enciclopedia Medica Italiana |
| Volume | 10 |
| Issue number | 1 |
| Publication status | Published - 1990 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
SISTEMA MONOCITO-MACROFAGICO E SINDROME DA IMMUNODEFICIENZA ACQUISITA (AIDS). / Ercoli, L.; Perno, C. F.; Bergamini, A.; Riocchi, G.
In: Medicina - Rivista della Enciclopedia Medica Italiana, Vol. 10, No. 1, 1990, p. 1-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - SISTEMA MONOCITO-MACROFAGICO E SINDROME DA IMMUNODEFICIENZA ACQUISITA (AIDS)
AU - Ercoli, L.
AU - Perno, C. F.
AU - Bergamini, A.
AU - Riocchi, G.
PY - 1990
Y1 - 1990
N2 - The pathogenesis of HIV infection and the definition of the cell types target of HIV is the crucial background for the improvement of the therapeutic strategies against HIV infection. Monocyte-macrophages (M/M) are easily infected by HIV, and play a crucial role in the maintenance and the progression of HIV-related disease; HIV infection of M/M is the principal cause of HIV-related 'dementia complex'. Thus it is crucial that drugs used in the therapy of HIV infection are active against HIV replicating in cells of M/M lineage. In this paper the interaction between HIV and M/M is analyzed and the characteristics of viral replication in these cells, and the in vitro antiviral activity of several drugs in M/M are discussed. These data suggest that patients should be treated with drugs, that inhibit HIV also in M/M and, consequently, are able to block the clinical manifestations related to M/M infection, such as 'dementia complex'.
AB - The pathogenesis of HIV infection and the definition of the cell types target of HIV is the crucial background for the improvement of the therapeutic strategies against HIV infection. Monocyte-macrophages (M/M) are easily infected by HIV, and play a crucial role in the maintenance and the progression of HIV-related disease; HIV infection of M/M is the principal cause of HIV-related 'dementia complex'. Thus it is crucial that drugs used in the therapy of HIV infection are active against HIV replicating in cells of M/M lineage. In this paper the interaction between HIV and M/M is analyzed and the characteristics of viral replication in these cells, and the in vitro antiviral activity of several drugs in M/M are discussed. These data suggest that patients should be treated with drugs, that inhibit HIV also in M/M and, consequently, are able to block the clinical manifestations related to M/M infection, such as 'dementia complex'.
UR - http://www.scopus.com/inward/record.url?scp=0025072715&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025072715&partnerID=8YFLogxK
M3 - Articolo
C2 - 2199742
AN - SCOPUS:0025072715
VL - 10
SP - 1
EP - 8
JO - Medicina - Rivista della Enciclopedia Medica Italiana
JF - Medicina - Rivista della Enciclopedia Medica Italiana
SN - 0392-6516
IS - 1
ER -