Monocyte production of IL-12 and thl profile of CD4+ cells in patients with multiple sclerosis

P. Sarchielli, M. Tognoloni, F. Vicinanza, An Orlacchio, C. Saccardi, G. P. Pelliccioli, V. Gallai

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IL-12 has been revealed to be a powerful inducer of the Th1 cell function. An upregulation of this cytokine in Multiple Sclerosis (MS) has been proposed, particularly in the active stages of the disease. In the present study, we determined the secretion of IL-12 in LPS-stimulated monocytes of 18 patients affected by MS in the relapsing-remitting form, and related this secretion with the production of cytokines of the Thl type by the CD4+ lymphocytes stimulated with PHA of the same patients. An increased monocyte secretion of IL-12 s was observed in 10 out of 18 MS patients examined. In all of them one or more gadolinium-enhancing lesions was evidenced at MRI examination. In the patients without active lesions the monocyte production of IL-12 did not significantly differ from that of the control individuals. Moreover the secretion of cytokines with an immunoenhancing action (IL2, IFN-y e TNF-a) was significantly increased in the CD4+ cells of the patients with high levels of IL-12 (p

Original languageEnglish
Pages (from-to)30
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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