Monocyte tumor necrosis factor production in head and neck squamous cell carcinoma

Oreste Gallo; Stefania Pinto; Simone Boccuzzi; Maurizio Dilaghi; Ezio Gallina; Monica Attanasio; Anna Maria Gori; Francesca Martini; Rosanna Abbate

Monocyte tumor necrosis factor production in head and neck squamous cell carcinoma

Oreste Gallo, Stefania Pinto, Simone Boccuzzi, Maurizio Dilaghi, Ezio Gallina, Monica Attanasio, Anna Maria Gori, Francesca Martini, Rosanna Abbate

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Changes in monocyte and macrophage function have been demonstrated in patients with head and neck squamous cell carcinoma. The purpose of this study was to evaluate tumor necrosis factor (TNT) production by activated monocytes from patients with head and neck squamous cell carcinoma and to evaluate its relation to cancer stage, weight loss, and performance status. Monocytes from patients (n = 10) and controls (n = 10) were isolated from peripheral blood mononuclear cells by plastic adherence and incubated with lipopolysaccharide (10 µg/mL). The TNF concentration of supernatants was assayed by TNFα-specific immunoassay. The TNF production by monocytes from head and neck squamous cell carcinoma patients was significantly higher (P

Original language	English
Pages (from-to)	447-450
Number of pages	4
Journal	Laryngoscope
Volume	102
Issue number	4
Publication status	Published - 1992

ASJC Scopus subject areas

Otorhinolaryngology

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abstract = "Changes in monocyte and macrophage function have been demonstrated in patients with head and neck squamous cell carcinoma. The purpose of this study was to evaluate tumor necrosis factor (TNT) production by activated monocytes from patients with head and neck squamous cell carcinoma and to evaluate its relation to cancer stage, weight loss, and performance status. Monocytes from patients (n = 10) and controls (n = 10) were isolated from peripheral blood mononuclear cells by plastic adherence and incubated with lipopolysaccharide (10 µg/mL). The TNF concentration of supernatants was assayed by TNFα-specific immunoassay. The TNF production by monocytes from head and neck squamous cell carcinoma patients was significantly higher (P",

author = "Oreste Gallo and Stefania Pinto and Simone Boccuzzi and Maurizio Dilaghi and Ezio Gallina and Monica Attanasio and {Maria Gori}, Anna and Francesca Martini and Rosanna Abbate",

year = "1992",

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T1 - Monocyte tumor necrosis factor production in head and neck squamous cell carcinoma

AU - Gallo, Oreste

AU - Pinto, Stefania

AU - Boccuzzi, Simone

AU - Dilaghi, Maurizio

AU - Gallina, Ezio

AU - Attanasio, Monica

AU - Maria Gori, Anna

AU - Martini, Francesca

AU - Abbate, Rosanna

PY - 1992

Y1 - 1992

N2 - Changes in monocyte and macrophage function have been demonstrated in patients with head and neck squamous cell carcinoma. The purpose of this study was to evaluate tumor necrosis factor (TNT) production by activated monocytes from patients with head and neck squamous cell carcinoma and to evaluate its relation to cancer stage, weight loss, and performance status. Monocytes from patients (n = 10) and controls (n = 10) were isolated from peripheral blood mononuclear cells by plastic adherence and incubated with lipopolysaccharide (10 µg/mL). The TNF concentration of supernatants was assayed by TNFα-specific immunoassay. The TNF production by monocytes from head and neck squamous cell carcinoma patients was significantly higher (P

AB - Changes in monocyte and macrophage function have been demonstrated in patients with head and neck squamous cell carcinoma. The purpose of this study was to evaluate tumor necrosis factor (TNT) production by activated monocytes from patients with head and neck squamous cell carcinoma and to evaluate its relation to cancer stage, weight loss, and performance status. Monocytes from patients (n = 10) and controls (n = 10) were isolated from peripheral blood mononuclear cells by plastic adherence and incubated with lipopolysaccharide (10 µg/mL). The TNF concentration of supernatants was assayed by TNFα-specific immunoassay. The TNF production by monocytes from head and neck squamous cell carcinoma patients was significantly higher (P

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