Monocyte tumor necrosis factor production in head and neck squamous cell carcinoma

Oreste Gallo, Stefania Pinto, Simone Boccuzzi, Maurizio Dilaghi, Ezio Gallina, Monica Attanasio, Anna Maria Gori, Francesca Martini, Rosanna Abbate

Research output: Contribution to journalArticlepeer-review

Abstract

Changes in monocyte and macrophage function have been demonstrated in patients with head and neck squamous cell carcinoma. The purpose of this study was to evaluate tumor necrosis factor (TNT) production by activated monocytes from patients with head and neck squamous cell carcinoma and to evaluate its relation to cancer stage, weight loss, and performance status. Monocytes from patients (n = 10) and controls (n = 10) were isolated from peripheral blood mononuclear cells by plastic adherence and incubated with lipopolysaccharide (10 µg/mL). The TNF concentration of supernatants was assayed by TNFα-specific immunoassay. The TNF production by monocytes from head and neck squamous cell carcinoma patients was significantly higher (P

Original languageEnglish
Pages (from-to)447-450
Number of pages4
JournalLaryngoscope
Volume102
Issue number4
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Otorhinolaryngology

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