Monogenic mouse models of social dysfunction: Implications for autism

D. Oddi, W. E. Crusio, F. R. D'Amato, S. Pietropaolo

Research output: Contribution to journalArticle

Abstract

Autism is a pervasive disorder characterized by a complex symptomatology, based principally on social dysfunction. The disorder has a highly complex, largely genetic etiology, involving an impressive variety of genes, the precise contributions of which still remain to be determined. For this reason, a reductionist approach to the study of autism has been proposed, employing monogenic animal models of social dysfunction, either by targeting a candidate gene, or by mimicking a single-gene disorder characterized by autistic symptoms. In the present review, we discuss this monogenic approach by comparing examples of each strategy: the mu opioid receptor knock-out (KO) mouse line, which targets the opioid system (known to be involved in the control of social behaviors); and the Fmr1-KO mouse, a model for Fragile X syndrome (a neurodevelopmental syndrome that includes autistic symptoms). The autistic-relevant behavioral phenotypes of the mu-opioid and Fmr1-KO mouse lines are described here, summarizing previous work by our research group and others, but also providing novel experimental evidence. Relevant factors influencing the validity of the two models, such as sex differences and age at testing, are also addressed, permitting an extensive evaluation of the advantages and limits of monogenic mouse models for autism.

Original languageEnglish
Pages (from-to)75-84
Number of pages10
JournalBehavioural Brain Research
Volume251
DOIs
Publication statusPublished - Aug 15 2013

Fingerprint

Autistic Disorder
Knockout Mice
Opioid Analgesics
Genes
Fragile X Syndrome
mu Opioid Receptor
Social Behavior
Sex Characteristics
Animal Models
Phenotype
Research

Keywords

  • Fmr1
  • Fragile X syndrome
  • Mouse models
  • Mu receptor
  • Opioid system
  • Social behaviors
  • Ultrasonic communication

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Monogenic mouse models of social dysfunction : Implications for autism. / Oddi, D.; Crusio, W. E.; D'Amato, F. R.; Pietropaolo, S.

In: Behavioural Brain Research, Vol. 251, 15.08.2013, p. 75-84.

Research output: Contribution to journalArticle

Oddi, D. ; Crusio, W. E. ; D'Amato, F. R. ; Pietropaolo, S. / Monogenic mouse models of social dysfunction : Implications for autism. In: Behavioural Brain Research. 2013 ; Vol. 251. pp. 75-84.
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