Monokine production by microglial cell clones

M. Righi, L. Mori, G. De Libero, M. Sironi, A. Biondi, A. Mantovani, S. D. Donini, P. Ricciardi-Castagnoli

Research output: Contribution to journalArticlepeer-review


Cytokines have been suggested to act as intermediates between the immune and the central nervous system, but little is known about the type of cells synthesizing them in the brain. We have immortalized with oncogenic retroviruses primary brain cell cultures from mouse embryos and have generated clones of microglial cells that have been characterized. Three of the clones studied produce interleukin 1 (IL 1), IL 6 and tumor necrosis factor-α as assessed by biological assays and by Northern blot analysis. Our data raise the question on the role of these cytokines in the brain and suggest that early resident microglial cells might play an important role in developmental processes and in the adult brain.

Original languageEnglish
Pages (from-to)1443-1448
Number of pages6
JournalEuropean Journal of Immunology
Issue number8
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Immunology


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