Mononuclear phagocyte adherence in the presence of laminin. A possible marker of cellular differentiation

R. Giavazzi, I. R. Hart

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of laminin on the vitro adhesive behavior of mononuclear phagocytes was investigated. Laminin significantly inhibited the adhesion of guinea pig, mouse, and rat alveolar or peritoneal macrophages and of human peripheral blood monocytes. Adhesion of these cells was unaffected by similar concentrations of fibronectin. Experiments performed with monocytes maintained in culture showed that the degree of laminin-mediated inhibition of adherence was dependent on the state of differentiation of the cells: the less mature the monocytes, the greater the degree of inhibition. Laminin also reduced the attachment capacity of polymorphonuclear leukocytes isolated from human peripheral blood. These results suggest a possible role for laminin in the regulation of the passage of cells across the basement membrane during inflammation.

Original languageEnglish
Pages (from-to)391-399
Number of pages9
JournalExperimental Cell Research
Volume146
Issue number2
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Cell Biology

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