Abstract
The effect of laminin on the vitro adhesive behavior of mononuclear phagocytes was investigated. Laminin significantly inhibited the adhesion of guinea pig, mouse, and rat alveolar or peritoneal macrophages and of human peripheral blood monocytes. Adhesion of these cells was unaffected by similar concentrations of fibronectin. Experiments performed with monocytes maintained in culture showed that the degree of laminin-mediated inhibition of adherence was dependent on the state of differentiation of the cells: the less mature the monocytes, the greater the degree of inhibition. Laminin also reduced the attachment capacity of polymorphonuclear leukocytes isolated from human peripheral blood. These results suggest a possible role for laminin in the regulation of the passage of cells across the basement membrane during inflammation.
| Original language | English |
|---|---|
| Pages (from-to) | 391-399 |
| Number of pages | 9 |
| Journal | Experimental Cell Research |
| Volume | 146 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1983 |
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Mononuclear phagocyte adherence in the presence of laminin. A possible marker of cellular differentiation. / Giavazzi, R.; Hart, I. R.
In: Experimental Cell Research, Vol. 146, No. 2, 1983, p. 391-399.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mononuclear phagocyte adherence in the presence of laminin. A possible marker of cellular differentiation
AU - Giavazzi, R.
AU - Hart, I. R.
PY - 1983
Y1 - 1983
N2 - The effect of laminin on the vitro adhesive behavior of mononuclear phagocytes was investigated. Laminin significantly inhibited the adhesion of guinea pig, mouse, and rat alveolar or peritoneal macrophages and of human peripheral blood monocytes. Adhesion of these cells was unaffected by similar concentrations of fibronectin. Experiments performed with monocytes maintained in culture showed that the degree of laminin-mediated inhibition of adherence was dependent on the state of differentiation of the cells: the less mature the monocytes, the greater the degree of inhibition. Laminin also reduced the attachment capacity of polymorphonuclear leukocytes isolated from human peripheral blood. These results suggest a possible role for laminin in the regulation of the passage of cells across the basement membrane during inflammation.
AB - The effect of laminin on the vitro adhesive behavior of mononuclear phagocytes was investigated. Laminin significantly inhibited the adhesion of guinea pig, mouse, and rat alveolar or peritoneal macrophages and of human peripheral blood monocytes. Adhesion of these cells was unaffected by similar concentrations of fibronectin. Experiments performed with monocytes maintained in culture showed that the degree of laminin-mediated inhibition of adherence was dependent on the state of differentiation of the cells: the less mature the monocytes, the greater the degree of inhibition. Laminin also reduced the attachment capacity of polymorphonuclear leukocytes isolated from human peripheral blood. These results suggest a possible role for laminin in the regulation of the passage of cells across the basement membrane during inflammation.
UR - http://www.scopus.com/inward/record.url?scp=0020957954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020957954&partnerID=8YFLogxK
U2 - 10.1016/0014-4827(83)90141-6
DO - 10.1016/0014-4827(83)90141-6
M3 - Article
VL - 146
SP - 391
EP - 399
JO - Experimental Cell Research
JF - Experimental Cell Research
SN - 0014-4827
IS - 2
ER -