TY - JOUR
T1 - Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population
AU - Insawang, Tonkla
AU - Selmi, Carlo
AU - Cha'on, Ubon
AU - Pethlert, Supattra
AU - Yongvanit, Puangrat
AU - Areejitranusorn, Premjai
AU - Boonsiri, Patcharee
AU - Khampitak, Tueanjit
AU - Tangrassameeprasert, Roongpet
AU - Pinitsoontorn, Chadamas
AU - Prasongwattana, Vitoon
AU - Gershwin, M. Eric
AU - Hammock, Bruce D.
PY - 2012
Y1 - 2012
N2 - Background: Epidemiology and animal models suggest that dietary monosodium glutamate (MSG) may contribute to the onset of obesity and the metabolic syndrome. Methods: Families (n = 324) from a rural area of Thailand were selected and provided MSG as the sole source for the use in meal preparation for 10 days. Three hundred forty-nine subjects aged 35.55 years completed the study and were evaluated for energy and nutrient intake, physical activity, and tobacco smoking. The prevalence of overweight and obesity (BMI ≥25 kg/m 2), insulin resistance (HOMA-IR >3), and the metabolic syndrome (ATP III criteria) were evaluated according to the daily MSG intake. Results: The prevalence of the metabolic syndrome was significantly higher in the tertile with the highest MSG intake. Further, every 1 g increase in MSG intake significantly increased the risk of having the metabolic syndrome (odds ratio 1.14, 95% confidence interval-CI- 1.12 - 1.28) or being overweight (odds ratio 1.16, 95% CI 1.04 - 1.29), independent of the total energy intake and the level of physical activity. Conclusion: Higher amounts of individual MSG consumption are associated with the risk of having the metabolic syndrome and being overweight independent of other major determinants.
AB - Background: Epidemiology and animal models suggest that dietary monosodium glutamate (MSG) may contribute to the onset of obesity and the metabolic syndrome. Methods: Families (n = 324) from a rural area of Thailand were selected and provided MSG as the sole source for the use in meal preparation for 10 days. Three hundred forty-nine subjects aged 35.55 years completed the study and were evaluated for energy and nutrient intake, physical activity, and tobacco smoking. The prevalence of overweight and obesity (BMI ≥25 kg/m 2), insulin resistance (HOMA-IR >3), and the metabolic syndrome (ATP III criteria) were evaluated according to the daily MSG intake. Results: The prevalence of the metabolic syndrome was significantly higher in the tertile with the highest MSG intake. Further, every 1 g increase in MSG intake significantly increased the risk of having the metabolic syndrome (odds ratio 1.14, 95% confidence interval-CI- 1.12 - 1.28) or being overweight (odds ratio 1.16, 95% CI 1.04 - 1.29), independent of the total energy intake and the level of physical activity. Conclusion: Higher amounts of individual MSG consumption are associated with the risk of having the metabolic syndrome and being overweight independent of other major determinants.
KW - Functional food
KW - Metabolic syndrome
KW - Obesity
KW - Thailand
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U2 - 10.1186/1743-7075-9-50
DO - 10.1186/1743-7075-9-50
M3 - Article
C2 - 22681873
AN - SCOPUS:84861950061
VL - 9
JO - Nutrition and Metabolism
JF - Nutrition and Metabolism
SN - 1743-7075
M1 - 50
ER -