Monosomal complex karyotype in pediatric mixed phenotype acute leukemia

Elisa Tassano; Elisa Tavella; Concetta Micalizzi; Francesca Scuderi; Cristina Cuoco; Cristina Morerio

doi:10.1016/j.cancergen.2011.08.015

Monosomal complex karyotype in pediatric mixed phenotype acute leukemia

Elisa Tassano, Elisa Tavella, Concetta Micalizzi, Francesca Scuderi, Cristina Cuoco, Cristina Morerio

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

We report on a pediatric case of mixed phenotype acute leukemia with myeloid and T-lymphoid differentiation, a single myeloblastic cell population, and a monosomal complex karyotype. The patient, a 5-year-old girl, responded to acute myeloid leukemia-oriented therapy that was decided based on the morphological appearance of blast cells. In this study, we analyzed the patient's peculiar chromosomal abnormalities, as evaluated by array comparative genomic hybridization in combination with multicolor fluorescence in situ hybridization and cytogenetic analyses.

Original language	English
Pages (from-to)	507-511
Number of pages	5
Journal	Cancer genetics
Volume	204
Issue number	9
DOIs	https://doi.org/10.1016/j.cancergen.2011.08.015
Publication status	Published - Sep 2011

Keywords

Array-based comparative genomic hybridization
Childhood
Mixed phenotype acute leukemia
Monosomal complex karyotype
Multicolor fluorescence in situ hybridization

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology
Medicine(all)

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10.1016/j.cancergen.2011.08.015

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title = "Monosomal complex karyotype in pediatric mixed phenotype acute leukemia",

abstract = "We report on a pediatric case of mixed phenotype acute leukemia with myeloid and T-lymphoid differentiation, a single myeloblastic cell population, and a monosomal complex karyotype. The patient, a 5-year-old girl, responded to acute myeloid leukemia-oriented therapy that was decided based on the morphological appearance of blast cells. In this study, we analyzed the patient's peculiar chromosomal abnormalities, as evaluated by array comparative genomic hybridization in combination with multicolor fluorescence in situ hybridization and cytogenetic analyses.",

keywords = "Array-based comparative genomic hybridization, Childhood, Mixed phenotype acute leukemia, Monosomal complex karyotype, Multicolor fluorescence in situ hybridization",

author = "Elisa Tassano and Elisa Tavella and Concetta Micalizzi and Francesca Scuderi and Cristina Cuoco and Cristina Morerio",

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AU - Tassano, Elisa

AU - Tavella, Elisa

AU - Micalizzi, Concetta

AU - Scuderi, Francesca

AU - Cuoco, Cristina

AU - Morerio, Cristina

PY - 2011/9

Y1 - 2011/9

N2 - We report on a pediatric case of mixed phenotype acute leukemia with myeloid and T-lymphoid differentiation, a single myeloblastic cell population, and a monosomal complex karyotype. The patient, a 5-year-old girl, responded to acute myeloid leukemia-oriented therapy that was decided based on the morphological appearance of blast cells. In this study, we analyzed the patient's peculiar chromosomal abnormalities, as evaluated by array comparative genomic hybridization in combination with multicolor fluorescence in situ hybridization and cytogenetic analyses.

AB - We report on a pediatric case of mixed phenotype acute leukemia with myeloid and T-lymphoid differentiation, a single myeloblastic cell population, and a monosomal complex karyotype. The patient, a 5-year-old girl, responded to acute myeloid leukemia-oriented therapy that was decided based on the morphological appearance of blast cells. In this study, we analyzed the patient's peculiar chromosomal abnormalities, as evaluated by array comparative genomic hybridization in combination with multicolor fluorescence in situ hybridization and cytogenetic analyses.

KW - Array-based comparative genomic hybridization

KW - Childhood

KW - Mixed phenotype acute leukemia

KW - Monosomal complex karyotype

KW - Multicolor fluorescence in situ hybridization

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Monosomal complex karyotype in pediatric mixed phenotype acute leukemia

Abstract

Keywords

ASJC Scopus subject areas

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