Monosomal complex karyotype in pediatric mixed phenotype acute leukemia

Elisa Tassano, Elisa Tavella, Concetta Micalizzi, Francesca Scuderi, Cristina Cuoco, Cristina Morerio

Research output: Contribution to journalArticlepeer-review

Abstract

We report on a pediatric case of mixed phenotype acute leukemia with myeloid and T-lymphoid differentiation, a single myeloblastic cell population, and a monosomal complex karyotype. The patient, a 5-year-old girl, responded to acute myeloid leukemia-oriented therapy that was decided based on the morphological appearance of blast cells. In this study, we analyzed the patient's peculiar chromosomal abnormalities, as evaluated by array comparative genomic hybridization in combination with multicolor fluorescence in situ hybridization and cytogenetic analyses.

Original languageEnglish
Pages (from-to)507-511
Number of pages5
JournalCancer genetics
Volume204
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Array-based comparative genomic hybridization
  • Childhood
  • Mixed phenotype acute leukemia
  • Monosomal complex karyotype
  • Multicolor fluorescence in situ hybridization

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology
  • Medicine(all)

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