Abstract
We report on a pediatric case of mixed phenotype acute leukemia with myeloid and T-lymphoid differentiation, a single myeloblastic cell population, and a monosomal complex karyotype. The patient, a 5-year-old girl, responded to acute myeloid leukemia-oriented therapy that was decided based on the morphological appearance of blast cells. In this study, we analyzed the patient's peculiar chromosomal abnormalities, as evaluated by array comparative genomic hybridization in combination with multicolor fluorescence in situ hybridization and cytogenetic analyses.
Original language | English |
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Pages (from-to) | 507-511 |
Number of pages | 5 |
Journal | Cancer genetics |
Volume | 204 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sep 2011 |
Keywords
- Array-based comparative genomic hybridization
- Childhood
- Mixed phenotype acute leukemia
- Monosomal complex karyotype
- Multicolor fluorescence in situ hybridization
ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
- Medicine(all)