Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: An international retrospective study

Henrik Hasle, Todd A. Alonzo, Anne Auvrignon, Catherine Behar, Myron Chang, Ursula Creutzig, Alexandra Fischer, Erik Forestier, Alcira Fynn, Oskar A. Haas, Jochen Harbott, Christine J. Harrison, Nyla A. Heerema, Marry M. Van Den Heuvel-Eibrink, Gertjan J L Kaspers, Franco Locatelli, Peter Noellke, Sophia Polychronopoulou, Yaddanapudi Ravindranath, Bassem RazzoukDirk Reinhardt, Natalia N. Savva, Batia Stark, Stefan Suciu, Ichiro Tsukimoto, David K. Webb, Dorora Wojcik, William G. Woods, Martin Zimmermann, Charlotte M. Niemeyer, Susana C. Raimondi

Research output: Contribution to journalArticle

Abstract

Monosomy 7 (-7) and deletion 7q [del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and -7 or del(7q) with or without other cytogenetic aberrations [± other]. Karyotypes included -7 (n = 90), -7 other (n = 82), del(7q) (n = 21), and del(7q) other (n = 65). Complete remission (CR) was achieved in fewer patients with -7 ± other compared with del(7q) ± other (61% versus 89%, P <.001). Overall, the 5-year survival rate was 39% (SE, 3%). Survival was superior in del(7q) ± other compared with -7 ± other (51% versus 30%, P <.01). Cytogenetic aberrations considered favorable in AML [t(8;21)(q22;q22), inv(16)(p13q22), t(15;17)(q22;q21), t(9;11)(p22;q23)] (n = 24) were strongly associated with del(7q) and a higher 5-year survival rate compared with del(7q) without favorable cytogenetics (75% versus 46%, P = .03). Patients with -7 and inv(3),-5/del(5q), or +21 had a 5-year survival rate of 5%. Stem cell transplantation analyzed as a time-dependent variable had no impact on overall survival. However, patients not achieving CR had a 31% survival rate after stem cell transplantation. Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future riskgroup stratification.

Original languageEnglish
Pages (from-to)4641-4647
Number of pages7
JournalBlood
Volume109
Issue number11
DOIs
Publication statusPublished - Jun 1 2007

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Aberrations
Acute Myeloid Leukemia
Chromosome Aberrations
Survival Rate
Retrospective Studies
Stem Cell Transplantation
Stem cells
Refractory Anemia with Excess of Blasts
Chromosomes, Human, Pair 7
Survival
Chromosomes
Lymphocyte Activation
Karyotype
Cytogenetics
Refractory materials
Monosomy Chromosome 7

ASJC Scopus subject areas

  • Hematology

Cite this

Hasle, H., Alonzo, T. A., Auvrignon, A., Behar, C., Chang, M., Creutzig, U., ... Raimondi, S. C. (2007). Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: An international retrospective study. Blood, 109(11), 4641-4647. https://doi.org/10.1182/blood-2006-10-051342

Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia : An international retrospective study. / Hasle, Henrik; Alonzo, Todd A.; Auvrignon, Anne; Behar, Catherine; Chang, Myron; Creutzig, Ursula; Fischer, Alexandra; Forestier, Erik; Fynn, Alcira; Haas, Oskar A.; Harbott, Jochen; Harrison, Christine J.; Heerema, Nyla A.; Van Den Heuvel-Eibrink, Marry M.; Kaspers, Gertjan J L; Locatelli, Franco; Noellke, Peter; Polychronopoulou, Sophia; Ravindranath, Yaddanapudi; Razzouk, Bassem; Reinhardt, Dirk; Savva, Natalia N.; Stark, Batia; Suciu, Stefan; Tsukimoto, Ichiro; Webb, David K.; Wojcik, Dorora; Woods, William G.; Zimmermann, Martin; Niemeyer, Charlotte M.; Raimondi, Susana C.

In: Blood, Vol. 109, No. 11, 01.06.2007, p. 4641-4647.

Research output: Contribution to journalArticle

Hasle, H, Alonzo, TA, Auvrignon, A, Behar, C, Chang, M, Creutzig, U, Fischer, A, Forestier, E, Fynn, A, Haas, OA, Harbott, J, Harrison, CJ, Heerema, NA, Van Den Heuvel-Eibrink, MM, Kaspers, GJL, Locatelli, F, Noellke, P, Polychronopoulou, S, Ravindranath, Y, Razzouk, B, Reinhardt, D, Savva, NN, Stark, B, Suciu, S, Tsukimoto, I, Webb, DK, Wojcik, D, Woods, WG, Zimmermann, M, Niemeyer, CM & Raimondi, SC 2007, 'Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: An international retrospective study', Blood, vol. 109, no. 11, pp. 4641-4647. https://doi.org/10.1182/blood-2006-10-051342
Hasle, Henrik ; Alonzo, Todd A. ; Auvrignon, Anne ; Behar, Catherine ; Chang, Myron ; Creutzig, Ursula ; Fischer, Alexandra ; Forestier, Erik ; Fynn, Alcira ; Haas, Oskar A. ; Harbott, Jochen ; Harrison, Christine J. ; Heerema, Nyla A. ; Van Den Heuvel-Eibrink, Marry M. ; Kaspers, Gertjan J L ; Locatelli, Franco ; Noellke, Peter ; Polychronopoulou, Sophia ; Ravindranath, Yaddanapudi ; Razzouk, Bassem ; Reinhardt, Dirk ; Savva, Natalia N. ; Stark, Batia ; Suciu, Stefan ; Tsukimoto, Ichiro ; Webb, David K. ; Wojcik, Dorora ; Woods, William G. ; Zimmermann, Martin ; Niemeyer, Charlotte M. ; Raimondi, Susana C. / Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia : An international retrospective study. In: Blood. 2007 ; Vol. 109, No. 11. pp. 4641-4647.
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abstract = "Monosomy 7 (-7) and deletion 7q [del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and -7 or del(7q) with or without other cytogenetic aberrations [± other]. Karyotypes included -7 (n = 90), -7 other (n = 82), del(7q) (n = 21), and del(7q) other (n = 65). Complete remission (CR) was achieved in fewer patients with -7 ± other compared with del(7q) ± other (61{\%} versus 89{\%}, P <.001). Overall, the 5-year survival rate was 39{\%} (SE, 3{\%}). Survival was superior in del(7q) ± other compared with -7 ± other (51{\%} versus 30{\%}, P <.01). Cytogenetic aberrations considered favorable in AML [t(8;21)(q22;q22), inv(16)(p13q22), t(15;17)(q22;q21), t(9;11)(p22;q23)] (n = 24) were strongly associated with del(7q) and a higher 5-year survival rate compared with del(7q) without favorable cytogenetics (75{\%} versus 46{\%}, P = .03). Patients with -7 and inv(3),-5/del(5q), or +21 had a 5-year survival rate of 5{\%}. Stem cell transplantation analyzed as a time-dependent variable had no impact on overall survival. However, patients not achieving CR had a 31{\%} survival rate after stem cell transplantation. Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future riskgroup stratification.",
author = "Henrik Hasle and Alonzo, {Todd A.} and Anne Auvrignon and Catherine Behar and Myron Chang and Ursula Creutzig and Alexandra Fischer and Erik Forestier and Alcira Fynn and Haas, {Oskar A.} and Jochen Harbott and Harrison, {Christine J.} and Heerema, {Nyla A.} and {Van Den Heuvel-Eibrink}, {Marry M.} and Kaspers, {Gertjan J L} and Franco Locatelli and Peter Noellke and Sophia Polychronopoulou and Yaddanapudi Ravindranath and Bassem Razzouk and Dirk Reinhardt and Savva, {Natalia N.} and Batia Stark and Stefan Suciu and Ichiro Tsukimoto and Webb, {David K.} and Dorora Wojcik and Woods, {William G.} and Martin Zimmermann and Niemeyer, {Charlotte M.} and Raimondi, {Susana C.}",
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T2 - An international retrospective study

AU - Hasle, Henrik

AU - Alonzo, Todd A.

AU - Auvrignon, Anne

AU - Behar, Catherine

AU - Chang, Myron

AU - Creutzig, Ursula

AU - Fischer, Alexandra

AU - Forestier, Erik

AU - Fynn, Alcira

AU - Haas, Oskar A.

AU - Harbott, Jochen

AU - Harrison, Christine J.

AU - Heerema, Nyla A.

AU - Van Den Heuvel-Eibrink, Marry M.

AU - Kaspers, Gertjan J L

AU - Locatelli, Franco

AU - Noellke, Peter

AU - Polychronopoulou, Sophia

AU - Ravindranath, Yaddanapudi

AU - Razzouk, Bassem

AU - Reinhardt, Dirk

AU - Savva, Natalia N.

AU - Stark, Batia

AU - Suciu, Stefan

AU - Tsukimoto, Ichiro

AU - Webb, David K.

AU - Wojcik, Dorora

AU - Woods, William G.

AU - Zimmermann, Martin

AU - Niemeyer, Charlotte M.

AU - Raimondi, Susana C.

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N2 - Monosomy 7 (-7) and deletion 7q [del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and -7 or del(7q) with or without other cytogenetic aberrations [± other]. Karyotypes included -7 (n = 90), -7 other (n = 82), del(7q) (n = 21), and del(7q) other (n = 65). Complete remission (CR) was achieved in fewer patients with -7 ± other compared with del(7q) ± other (61% versus 89%, P <.001). Overall, the 5-year survival rate was 39% (SE, 3%). Survival was superior in del(7q) ± other compared with -7 ± other (51% versus 30%, P <.01). Cytogenetic aberrations considered favorable in AML [t(8;21)(q22;q22), inv(16)(p13q22), t(15;17)(q22;q21), t(9;11)(p22;q23)] (n = 24) were strongly associated with del(7q) and a higher 5-year survival rate compared with del(7q) without favorable cytogenetics (75% versus 46%, P = .03). Patients with -7 and inv(3),-5/del(5q), or +21 had a 5-year survival rate of 5%. Stem cell transplantation analyzed as a time-dependent variable had no impact on overall survival. However, patients not achieving CR had a 31% survival rate after stem cell transplantation. Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future riskgroup stratification.

AB - Monosomy 7 (-7) and deletion 7q [del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and -7 or del(7q) with or without other cytogenetic aberrations [± other]. Karyotypes included -7 (n = 90), -7 other (n = 82), del(7q) (n = 21), and del(7q) other (n = 65). Complete remission (CR) was achieved in fewer patients with -7 ± other compared with del(7q) ± other (61% versus 89%, P <.001). Overall, the 5-year survival rate was 39% (SE, 3%). Survival was superior in del(7q) ± other compared with -7 ± other (51% versus 30%, P <.01). Cytogenetic aberrations considered favorable in AML [t(8;21)(q22;q22), inv(16)(p13q22), t(15;17)(q22;q21), t(9;11)(p22;q23)] (n = 24) were strongly associated with del(7q) and a higher 5-year survival rate compared with del(7q) without favorable cytogenetics (75% versus 46%, P = .03). Patients with -7 and inv(3),-5/del(5q), or +21 had a 5-year survival rate of 5%. Stem cell transplantation analyzed as a time-dependent variable had no impact on overall survival. However, patients not achieving CR had a 31% survival rate after stem cell transplantation. Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future riskgroup stratification.

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