Monotherapy with lopinavir/ritonavir versus standard of care in HIV-infected patients virologically suppressed while on treatment with protease inhibitor-based regimens: Results from the MoLo Study

Nicola Gianotti, Andrea Poli, Massimo Galli, Angelo Pan, Giuliano Rizzardini, Alessandro Soria, Pierluigi Viale, Antonio Di Biagio, Tiziana Quirino, Paolo Viganò, Paolo Bonfanti, Antonella D'Arminio Monforte, Ida Fortino, Adriano Lazzarin

Research output: Contribution to journalArticle

Abstract

This study compared the cost-efficacy ratios of lopinavir/ritonavir monotherapy (LPV/r-MT) and of standard of care in virologically suppressed HIV-infected patients. The results of the efficacy and safety analyses are presented. We conducted a multicentre, randomised, open-label trial of HIV-infected adults on stable treatment, with HIVRNA 2 per month; p=0.029]. LPV/r-MT seems safe in most patients and should be considered in patients who have developed kidney toxicity from tenofovir.

Original languageEnglish
Pages (from-to)439-448
Number of pages10
JournalNew Microbiologica
Volume37
Issue number4
Publication statusPublished - Oct 1 2014

Keywords

  • EGFR
  • HIV
  • Lopinavir/ritonavir
  • Monotherapy
  • Protease inhibitor
  • Randomized clinical trial

ASJC Scopus subject areas

  • Microbiology (medical)
  • Medicine(all)

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    Gianotti, N., Poli, A., Galli, M., Pan, A., Rizzardini, G., Soria, A., Viale, P., Di Biagio, A., Quirino, T., Viganò, P., Bonfanti, P., D'Arminio Monforte, A., Fortino, I., & Lazzarin, A. (2014). Monotherapy with lopinavir/ritonavir versus standard of care in HIV-infected patients virologically suppressed while on treatment with protease inhibitor-based regimens: Results from the MoLo Study. New Microbiologica, 37(4), 439-448.