Monte Carlo feasibility study for in vivo small animals beta detection: From beta to cerenkov luminescence imaging

Luisa Altabella; Carmen R. Gigliotti; Antonello E. Spinelli

doi:10.1109/NSSMIC.2015.7582145

Monte Carlo feasibility study for in vivo small animals beta detection: From beta to cerenkov luminescence imaging

Luisa Altabella, Carmen R. Gigliotti, Antonello E. Spinelli

IRCCS Ospedale San Raffaele

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this work we investigated using Monte Carlo simulations the feasibility of beta imaging of small animals with CLI, direct and indirect beta detection and bremsstrahlung using beta minus emitters. This study shows pro and cons of the different physical approaches for beta emitter imaging for small animals. Monte Carlo simulations were implemented using GAMOS plugin for GEANT4 considering a slab of mouse muscle and a radioactive source (³²P or ⁹⁰Y) placed at 0.5 mm depth. We found that direct beta detection and CLI are best approaches in term of resolution while the use of a thin scintillator increases the signal but the spatial resolution is degraded. Bremsstrahlung presents lower signal and it does not represent the best choice in small animal imaging. We conclude that CLI is a more flexible approach for in vivo beta minus emitter imaging.

Original language	English
Title of host publication	2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781467398626
DOIs	https://doi.org/10.1109/NSSMIC.2015.7582145
Publication status	Published - Oct 3 2016
Event	2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 - San Diego, United States Duration: Oct 31 2015 → Nov 7 2015

Other

Other	2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
Country	United States
City	San Diego
Period	10/31/15 → 11/7/15

ASJC Scopus subject areas

Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging
Instrumentation

Access to Document

10.1109/NSSMIC.2015.7582145

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Monte Carlo feasibility study for in vivo small animals beta detection : From beta to cerenkov luminescence imaging. / Altabella, Luisa; Gigliotti, Carmen R.; Spinelli, Antonello E.

2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. Institute of Electrical and Electronics Engineers Inc., 2016. 7582145.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Altabella, L, Gigliotti, CR & Spinelli, AE 2016, Monte Carlo feasibility study for in vivo small animals beta detection: From beta to cerenkov luminescence imaging. in 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015., 7582145, Institute of Electrical and Electronics Engineers Inc., 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015, San Diego, United States, 10/31/15. https://doi.org/10.1109/NSSMIC.2015.7582145

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abstract = "In this work we investigated using Monte Carlo simulations the feasibility of beta imaging of small animals with CLI, direct and indirect beta detection and bremsstrahlung using beta minus emitters. This study shows pro and cons of the different physical approaches for beta emitter imaging for small animals. Monte Carlo simulations were implemented using GAMOS plugin for GEANT4 considering a slab of mouse muscle and a radioactive source (32P or 90Y) placed at 0.5 mm depth. We found that direct beta detection and CLI are best approaches in term of resolution while the use of a thin scintillator increases the signal but the spatial resolution is degraded. Bremsstrahlung presents lower signal and it does not represent the best choice in small animal imaging. We conclude that CLI is a more flexible approach for in vivo beta minus emitter imaging.",

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