Mood disorders and multiple sclerosis: A study on 65 patients

A. Salmaggi, R. Palumbo, L. Fontanillas, F. Del Ton, M. Eoli, L. Lamantia, A. Solari, A. Sghirlanzoni, C. Milanese

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Discrepant results are reported in the literature about prevalence of mood disorders in MS; moreover, there are conflicting data about the relationship between presence of mood disorders and cognitive defects and/or disability. We have studied 65 MS patients and 31 patients with polyneuropathies (PNP). Patients have undergone a structured interview based on DSMIV by a trained psychiatrist, with anamnestic evaluation of previous mood disorders, as well as administration of Hamilton and Beck depression rating scales, and complete neurological evaluation with disability scoring according to Kurtzke. In 48 of 65 MS patients, a cognitive evaluation has also been performed (Token test. Attention matrices test, PM47, subtests of logical memory and block design of WAIS). The results confirm the high prevalence of major mood disorders in MS (p=0.001 by logrank test) in comparison with PNP No clearcut relationship has been detetced between presence of mood disorders and cognitive deterioration and/or neurological disability.

Original languageEnglish
Pages (from-to)76
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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