Mood disorders and sexual functioning in women with functional hypothalamic amenorrhea

Carolyn M. Dundon, Alessandra H. Rellini, Silvia Tonani, Valentina Santamaria, Rosella Nappi

Research output: Contribution to journalArticlepeer-review


Objective: To investigate the sexual function of women with functional hypothalamic amenorrhea (FHA) and to test the mediating effects of depression and anxiety on the sexual functioning of women with FHA. Design: In this cross-sectional study, participants completed questionnaires on sexual function, depression, and anxiety. Setting: Tertiary care university hospital. Patient(s): Women with (n = 41) and without (n = 39) FHA recruited from a gynecologic endocrinology unit. Intervention(s): None. Main Outcome Measure(s): The McCoy Female Sexuality Questionnaire assessed sexual function, and the Zung Scale measured depression and anxiety. Result(s): Women with FHA experienced more sexual function problems and significantly higher depression and anxiety compared to women without menstrual dysfunction. In addition, depression offered a significant explanation for the sexual problems experienced by women with FHA. Conclusion(s): The psychologic symptoms that contribute to the onset of FHA partially mediate the relationship between FHA and sexual dysfunction.

Original languageEnglish
Pages (from-to)2239-2243
Number of pages5
JournalFertility and Sterility
Issue number6
Publication statusPublished - Nov 2010


  • anxiety
  • depression
  • Functional hypothalamic amenorrhea
  • sexual dysfunction

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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