Morbidity and accidents in patients with epilepsy: Results of a European cohort study

Ettore Beghi; Cesare Cornaggia; L. M. Specchio; N. Specchio; E. Boati; C. A. Defanti; P. Pinto; E. Breviario; M. P. Pasolini; L. Antonini; A. Tiberti; D. Valseriati; U. Aguglia; C. Russo; A. Gambardella; S. Giubergia; P. Zagnoni; M. Cosottini; G. Zaccara; F. Pisani; G. Oteri; C. E. Cavestro; A. David; C. Tonini; G. Avanzini; F. Arienti; M. Beghi; G. Bogliun; E. Fiordelli; L. Airoldi; A. Mascarini; L. Mapelli; L. Moltrasio; A. Tartara; R. Manni; G. Castelnovo; R. Murelli; C. A. Galimberti; N. Zanotta; P. Di Viesti; M. Zarrelli; F. Apollo; E. Steuernagel; P. Wolf; U. Runge; M. C T F M De Krom; C. Van Heijden; J. Griet; M. W C Van Den Broek; S. W. Brown; H. Coyle; J. M. Lopes-Lima; P. Beleza; E. Ferreira; T. Talvik; A. Beilmann; E. Belousova; M. Nikanorowa; S. Gromov; L. V. Lipatova; V. Mikhailov; I. M. Ravnik; T. Levart; N. Zupancic; W. A. Hauser; J. N. Loeber; R. Thorbecke; A. E H Sonnen

doi:10.1046/j.1528-1157.2002.18701.x

Morbidity and accidents in patients with epilepsy: Results of a European cohort study

Ettore Beghi, Cesare Cornaggia, L. M. Specchio, N. Specchio, E. Boati, C. A. Defanti, P. Pinto, E. Breviario, M. P. Pasolini, L. Antonini, A. Tiberti, D. Valseriati, U. Aguglia, C. Russo, A. Gambardella, S. Giubergia, P. Zagnoni, M. Cosottini, G. Zaccara, F. PisaniG. Oteri, C. E. Cavestro, A. David, C. Tonini, G. Avanzini, F. Arienti, M. Beghi, G. Bogliun, E. Fiordelli, L. Airoldi, A. Mascarini, L. Mapelli, L. Moltrasio, A. Tartara, R. Manni, G. Castelnovo, R. Murelli, C. A. Galimberti, N. Zanotta, P. Di Viesti, M. Zarrelli, F. Apollo, E. Steuernagel, P. Wolf, U. Runge, M. C T F M De Krom, C. Van Heijden, J. Griet, M. W C Van Den Broek, S. W. Brown, H. Coyle, J. M. Lopes-Lima, P. Beleza, E. Ferreira, T. Talvik, A. Beilmann, E. Belousova, M. Nikanorowa, S. Gromov, L. V. Lipatova, V. Mikhailov, I. M. Ravnik, T. Levart, N. Zupancic, W. A. Hauser, J. N. Loeber, R. Thorbecke, A. E H Sonnen

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To assess the risk of illnesses and accidents in patients with epilepsy and to evaluate the proportion of those risks attributable to epilepsy. Methods: Nine hundred fifty-one referral patients with idiopathic, cryptogenic, or remote symptomatic epilepsy and 909 matched controls (relatives or friends) were followed up prospectively for 1-2 years in eight European countries (Italy, Germany, Holland, England, Portugal, Russia, Estonia, and Slovenia). Each patient and control received a diary to keep notes regarding any illness or accident. Patients with epilepsy specifically recorded relations with seizures. Results: Six hundred forty-four patients recorded 2,491 illnesses compared with 1,665 illnesses in 508 controls. The cumulative probability of illness in patients was 49% by 12 months and 86% by 24 months (controls, 39 and 75%; p <0.0001). One hundred ninety-nine patients and 124 controls had 270 and 140 accidents, respectively. The cumulative probability of accident in the cases was 17 and 27% by 12 and 24 months (controls, 12 and 17%; p <0.0001). The chance of two or more illnesses or accidents was modestly but significantly greater in the patients. Illnesses and accidents were mostly trivial. Thirty percent of illnesses and 24% of accidents were seizure related. When illnesses and accidents related to seizures were excluded, the chance of illnesses and accidents was fairly similar in the two groups. Conclusions: Patients with idiopathic, cryptogenic, or remote symptomatic epilepsy have a moderately higher risk of illnesses and accidents than do the general population. With few exceptions, the events are trivial. When seizure-related events are excluded, patients with epilepsy are not at any significantly higher risk of illnesses and accidents.

Original language	English
Pages (from-to)	1076-1083
Number of pages	8
Journal	Epilepsia
Volume	43
Issue number	9
DOIs	https://doi.org/10.1046/j.1528-1157.2002.18701.x
Publication status	Published - Sep 2002

Keywords

Accidents
Epilepsy
Illnesses
Injuries
Morbidity

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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Beghi, E., Cornaggia, C., Specchio, L. M., Specchio, N., Boati, E., Defanti, C. A., Pinto, P., Breviario, E., Pasolini, M. P., Antonini, L., Tiberti, A., Valseriati, D., Aguglia, U., Russo, C., Gambardella, A., Giubergia, S., Zagnoni, P., Cosottini, M., Zaccara, G., ... Sonnen, A. E. H. (2002). Morbidity and accidents in patients with epilepsy: Results of a European cohort study. Epilepsia, 43(9), 1076-1083. https://doi.org/10.1046/j.1528-1157.2002.18701.x

Morbidity and accidents in patients with epilepsy : Results of a European cohort study. / Beghi, Ettore; Cornaggia, Cesare; Specchio, L. M.; Specchio, N.; Boati, E.; Defanti, C. A.; Pinto, P.; Breviario, E.; Pasolini, M. P.; Antonini, L.; Tiberti, A.; Valseriati, D.; Aguglia, U.; Russo, C.; Gambardella, A.; Giubergia, S.; Zagnoni, P.; Cosottini, M.; Zaccara, G.; Pisani, F.; Oteri, G.; Cavestro, C. E.; David, A.; Tonini, C.; Avanzini, G.; Arienti, F.; Beghi, M.; Bogliun, G.; Fiordelli, E.; Airoldi, L.; Mascarini, A.; Mapelli, L.; Moltrasio, L.; Tartara, A.; Manni, R.; Castelnovo, G.; Murelli, R.; Galimberti, C. A.; Zanotta, N.; Di Viesti, P.; Zarrelli, M.; Apollo, F.; Steuernagel, E.; Wolf, P.; Runge, U.; De Krom, M. C T F M; Van Heijden, C.; Griet, J.; Van Den Broek, M. W C; Brown, S. W.; Coyle, H.; Lopes-Lima, J. M.; Beleza, P.; Ferreira, E.; Talvik, T.; Beilmann, A.; Belousova, E.; Nikanorowa, M.; Gromov, S.; Lipatova, L. V.; Mikhailov, V.; Ravnik, I. M.; Levart, T.; Zupancic, N.; Hauser, W. A.; Loeber, J. N.; Thorbecke, R.; Sonnen, A. E H.

In: Epilepsia, Vol. 43, No. 9, 09.2002, p. 1076-1083.

Research output: Contribution to journal › Article › peer-review

Beghi, E, Cornaggia, C, Specchio, LM, Specchio, N, Boati, E, Defanti, CA, Pinto, P, Breviario, E, Pasolini, MP, Antonini, L, Tiberti, A, Valseriati, D, Aguglia, U, Russo, C, Gambardella, A, Giubergia, S, Zagnoni, P, Cosottini, M, Zaccara, G, Pisani, F, Oteri, G, Cavestro, CE, David, A, Tonini, C, Avanzini, G, Arienti, F, Beghi, M, Bogliun, G, Fiordelli, E, Airoldi, L, Mascarini, A, Mapelli, L, Moltrasio, L, Tartara, A, Manni, R, Castelnovo, G, Murelli, R, Galimberti, CA, Zanotta, N, Di Viesti, P, Zarrelli, M, Apollo, F, Steuernagel, E, Wolf, P, Runge, U, De Krom, MCTFM, Van Heijden, C, Griet, J, Van Den Broek, MWC, Brown, SW, Coyle, H, Lopes-Lima, JM, Beleza, P, Ferreira, E, Talvik, T, Beilmann, A, Belousova, E, Nikanorowa, M, Gromov, S, Lipatova, LV, Mikhailov, V, Ravnik, IM, Levart, T, Zupancic, N, Hauser, WA, Loeber, JN, Thorbecke, R & Sonnen, AEH 2002, 'Morbidity and accidents in patients with epilepsy: Results of a European cohort study', Epilepsia, vol. 43, no. 9, pp. 1076-1083. https://doi.org/10.1046/j.1528-1157.2002.18701.x

Beghi, Ettore ; Cornaggia, Cesare ; Specchio, L. M. ; Specchio, N. ; Boati, E. ; Defanti, C. A. ; Pinto, P. ; Breviario, E. ; Pasolini, M. P. ; Antonini, L. ; Tiberti, A. ; Valseriati, D. ; Aguglia, U. ; Russo, C. ; Gambardella, A. ; Giubergia, S. ; Zagnoni, P. ; Cosottini, M. ; Zaccara, G. ; Pisani, F. ; Oteri, G. ; Cavestro, C. E. ; David, A. ; Tonini, C. ; Avanzini, G. ; Arienti, F. ; Beghi, M. ; Bogliun, G. ; Fiordelli, E. ; Airoldi, L. ; Mascarini, A. ; Mapelli, L. ; Moltrasio, L. ; Tartara, A. ; Manni, R. ; Castelnovo, G. ; Murelli, R. ; Galimberti, C. A. ; Zanotta, N. ; Di Viesti, P. ; Zarrelli, M. ; Apollo, F. ; Steuernagel, E. ; Wolf, P. ; Runge, U. ; De Krom, M. C T F M ; Van Heijden, C. ; Griet, J. ; Van Den Broek, M. W C ; Brown, S. W. ; Coyle, H. ; Lopes-Lima, J. M. ; Beleza, P. ; Ferreira, E. ; Talvik, T. ; Beilmann, A. ; Belousova, E. ; Nikanorowa, M. ; Gromov, S. ; Lipatova, L. V. ; Mikhailov, V. ; Ravnik, I. M. ; Levart, T. ; Zupancic, N. ; Hauser, W. A. ; Loeber, J. N. ; Thorbecke, R. ; Sonnen, A. E H. / Morbidity and accidents in patients with epilepsy : Results of a European cohort study. In: Epilepsia. 2002 ; Vol. 43, No. 9. pp. 1076-1083.

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abstract = "Purpose: To assess the risk of illnesses and accidents in patients with epilepsy and to evaluate the proportion of those risks attributable to epilepsy. Methods: Nine hundred fifty-one referral patients with idiopathic, cryptogenic, or remote symptomatic epilepsy and 909 matched controls (relatives or friends) were followed up prospectively for 1-2 years in eight European countries (Italy, Germany, Holland, England, Portugal, Russia, Estonia, and Slovenia). Each patient and control received a diary to keep notes regarding any illness or accident. Patients with epilepsy specifically recorded relations with seizures. Results: Six hundred forty-four patients recorded 2,491 illnesses compared with 1,665 illnesses in 508 controls. The cumulative probability of illness in patients was 49% by 12 months and 86% by 24 months (controls, 39 and 75%; p <0.0001). One hundred ninety-nine patients and 124 controls had 270 and 140 accidents, respectively. The cumulative probability of accident in the cases was 17 and 27% by 12 and 24 months (controls, 12 and 17%; p <0.0001). The chance of two or more illnesses or accidents was modestly but significantly greater in the patients. Illnesses and accidents were mostly trivial. Thirty percent of illnesses and 24% of accidents were seizure related. When illnesses and accidents related to seizures were excluded, the chance of illnesses and accidents was fairly similar in the two groups. Conclusions: Patients with idiopathic, cryptogenic, or remote symptomatic epilepsy have a moderately higher risk of illnesses and accidents than do the general population. With few exceptions, the events are trivial. When seizure-related events are excluded, patients with epilepsy are not at any significantly higher risk of illnesses and accidents.",

keywords = "Accidents, Epilepsy, Illnesses, Injuries, Morbidity",

author = "Ettore Beghi and Cesare Cornaggia and Specchio, {L. M.} and N. Specchio and E. Boati and Defanti, {C. A.} and P. Pinto and E. Breviario and Pasolini, {M. P.} and L. Antonini and A. Tiberti and D. Valseriati and U. Aguglia and C. Russo and A. Gambardella and S. Giubergia and P. Zagnoni and M. Cosottini and G. Zaccara and F. Pisani and G. Oteri and Cavestro, {C. E.} and A. David and C. Tonini and G. Avanzini and F. Arienti and M. Beghi and G. Bogliun and E. Fiordelli and L. Airoldi and A. Mascarini and L. Mapelli and L. Moltrasio and A. Tartara and R. Manni and G. Castelnovo and R. Murelli and Galimberti, {C. A.} and N. Zanotta and {Di Viesti}, P. and M. Zarrelli and F. Apollo and E. Steuernagel and P. Wolf and U. Runge and {De Krom}, {M. C T F M} and {Van Heijden}, C. and J. Griet and {Van Den Broek}, {M. W C} and Brown, {S. W.} and H. Coyle and Lopes-Lima, {J. M.} and P. Beleza and E. Ferreira and T. Talvik and A. Beilmann and E. Belousova and M. Nikanorowa and S. Gromov and Lipatova, {L. V.} and V. Mikhailov and Ravnik, {I. M.} and T. Levart and N. Zupancic and Hauser, {W. A.} and Loeber, {J. N.} and R. Thorbecke and Sonnen, {A. E H}",

year = "2002",

month = sep,

doi = "10.1046/j.1528-1157.2002.18701.x",

language = "English",

volume = "43",

pages = "1076--1083",

journal = "Epilepsia",

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TY - JOUR

T1 - Morbidity and accidents in patients with epilepsy

T2 - Results of a European cohort study

AU - Beghi, Ettore

AU - Cornaggia, Cesare

AU - Specchio, L. M.

AU - Specchio, N.

AU - Boati, E.

AU - Defanti, C. A.

AU - Pinto, P.

AU - Breviario, E.

AU - Pasolini, M. P.

AU - Antonini, L.

AU - Tiberti, A.

AU - Valseriati, D.

AU - Aguglia, U.

AU - Russo, C.

AU - Gambardella, A.

AU - Giubergia, S.

AU - Zagnoni, P.

AU - Cosottini, M.

AU - Zaccara, G.

AU - Pisani, F.

AU - Oteri, G.

AU - Cavestro, C. E.

AU - David, A.

AU - Tonini, C.

AU - Avanzini, G.

AU - Arienti, F.

AU - Beghi, M.

AU - Bogliun, G.

AU - Fiordelli, E.

AU - Airoldi, L.

AU - Mascarini, A.

AU - Mapelli, L.

AU - Moltrasio, L.

AU - Tartara, A.

AU - Manni, R.

AU - Castelnovo, G.

AU - Murelli, R.

AU - Galimberti, C. A.

AU - Zanotta, N.

AU - Di Viesti, P.

AU - Zarrelli, M.

AU - Apollo, F.

AU - Steuernagel, E.

AU - Wolf, P.

AU - Runge, U.

AU - De Krom, M. C T F M

AU - Van Heijden, C.

AU - Griet, J.

AU - Van Den Broek, M. W C

AU - Brown, S. W.

AU - Coyle, H.

AU - Lopes-Lima, J. M.

AU - Beleza, P.

AU - Ferreira, E.

AU - Talvik, T.

AU - Beilmann, A.

AU - Belousova, E.

AU - Nikanorowa, M.

AU - Gromov, S.

AU - Lipatova, L. V.

AU - Mikhailov, V.

AU - Ravnik, I. M.

AU - Levart, T.

AU - Zupancic, N.

AU - Hauser, W. A.

AU - Loeber, J. N.

AU - Thorbecke, R.

AU - Sonnen, A. E H

PY - 2002/9

Y1 - 2002/9

N2 - Purpose: To assess the risk of illnesses and accidents in patients with epilepsy and to evaluate the proportion of those risks attributable to epilepsy. Methods: Nine hundred fifty-one referral patients with idiopathic, cryptogenic, or remote symptomatic epilepsy and 909 matched controls (relatives or friends) were followed up prospectively for 1-2 years in eight European countries (Italy, Germany, Holland, England, Portugal, Russia, Estonia, and Slovenia). Each patient and control received a diary to keep notes regarding any illness or accident. Patients with epilepsy specifically recorded relations with seizures. Results: Six hundred forty-four patients recorded 2,491 illnesses compared with 1,665 illnesses in 508 controls. The cumulative probability of illness in patients was 49% by 12 months and 86% by 24 months (controls, 39 and 75%; p <0.0001). One hundred ninety-nine patients and 124 controls had 270 and 140 accidents, respectively. The cumulative probability of accident in the cases was 17 and 27% by 12 and 24 months (controls, 12 and 17%; p <0.0001). The chance of two or more illnesses or accidents was modestly but significantly greater in the patients. Illnesses and accidents were mostly trivial. Thirty percent of illnesses and 24% of accidents were seizure related. When illnesses and accidents related to seizures were excluded, the chance of illnesses and accidents was fairly similar in the two groups. Conclusions: Patients with idiopathic, cryptogenic, or remote symptomatic epilepsy have a moderately higher risk of illnesses and accidents than do the general population. With few exceptions, the events are trivial. When seizure-related events are excluded, patients with epilepsy are not at any significantly higher risk of illnesses and accidents.

AB - Purpose: To assess the risk of illnesses and accidents in patients with epilepsy and to evaluate the proportion of those risks attributable to epilepsy. Methods: Nine hundred fifty-one referral patients with idiopathic, cryptogenic, or remote symptomatic epilepsy and 909 matched controls (relatives or friends) were followed up prospectively for 1-2 years in eight European countries (Italy, Germany, Holland, England, Portugal, Russia, Estonia, and Slovenia). Each patient and control received a diary to keep notes regarding any illness or accident. Patients with epilepsy specifically recorded relations with seizures. Results: Six hundred forty-four patients recorded 2,491 illnesses compared with 1,665 illnesses in 508 controls. The cumulative probability of illness in patients was 49% by 12 months and 86% by 24 months (controls, 39 and 75%; p <0.0001). One hundred ninety-nine patients and 124 controls had 270 and 140 accidents, respectively. The cumulative probability of accident in the cases was 17 and 27% by 12 and 24 months (controls, 12 and 17%; p <0.0001). The chance of two or more illnesses or accidents was modestly but significantly greater in the patients. Illnesses and accidents were mostly trivial. Thirty percent of illnesses and 24% of accidents were seizure related. When illnesses and accidents related to seizures were excluded, the chance of illnesses and accidents was fairly similar in the two groups. Conclusions: Patients with idiopathic, cryptogenic, or remote symptomatic epilepsy have a moderately higher risk of illnesses and accidents than do the general population. With few exceptions, the events are trivial. When seizure-related events are excluded, patients with epilepsy are not at any significantly higher risk of illnesses and accidents.

KW - Accidents

KW - Epilepsy

KW - Illnesses

KW - Injuries

KW - Morbidity

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