Morphine and memory in DBA/2 mice: Effects of stress and of prior experience

Claudio Castellano, Flaminia Pavone, Stefano Puglisi Allegra

Research output: Contribution to journalArticlepeer-review


In a first set of experiments, immediately post-training morphine (1.0 or 2.5 but not 0.5 mg/kg) treatment, or immobilization stress (30 or 60 but not 15 min) impaired memory processes of non-pretrained DBA/2 mice tested in a passive avoidance box. The effects were naloxone-reversible and time-dependent (they were absent in mice injected with morphine, or immobilized, starting 120 min after training). No effect was evident in no-footshock groups injected with morphine (2.5 mg/kg) or immobilized (60 min), thus showing lack of proactive influence of the treatments on performance. In a second set of experiments, in which pretrained animals were used, both morphine and immobilization stress were less effective in disrupting memory processes of mice. In both sets of experiments a per se ineffective stress enhanced the effects of morphine. A number of possible hypotheses concerning the results obtained are examined. In particular the possible role of emotional factors in the effects of morphine on memory is discussed.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalBehavioural Brain Research
Issue number1
Publication statusPublished - 1984


  • DBA mice
  • familiarization
  • immobilization stress
  • morphine
  • passive avoidance

ASJC Scopus subject areas

  • Behavioral Neuroscience


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