Abstract
The action of morphine on spontaneous and stimulus-evoked postsynaptic potentials was investigated in rat cortical neurons recorded intracellularly in vivo. Iontophoretically applied, morphine increased supra-threshold evoked depolarizing postsynaptic potentials inducing bursts of spikes, but only slightly increased weak (subthreshold) potentials. Spontaneous excitatory postsynaptic potentials were affected in a similar way, but their frequency did not change. Inhibitory postsynaptic potentials were only subsequently modified. Membrane hyperpolarization, induced by negative current injection, counteracts the morphine-induced burst generation. We suggest that the action of this alkaloid on threshold postsynaptic events involves a voltage-dependent mechanism, which may be triggered by synaptic currents.
| Original language | English |
|---|---|
| Pages (from-to) | 45-53 |
| Number of pages | 9 |
| Journal | Neuroscience |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Morphine induces a spontaneous and evoked bursting activity in rat cortical neurons by adding a postsynaptic active mechanism to the synaptic input : An intracellular study In vivo. / Stanzione, P.; Stefani, A.; Bernardi, G.
In: Neuroscience, Vol. 26, No. 1, 1988, p. 45-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Morphine induces a spontaneous and evoked bursting activity in rat cortical neurons by adding a postsynaptic active mechanism to the synaptic input
T2 - An intracellular study In vivo
AU - Stanzione, P.
AU - Stefani, A.
AU - Bernardi, G.
PY - 1988
Y1 - 1988
N2 - The action of morphine on spontaneous and stimulus-evoked postsynaptic potentials was investigated in rat cortical neurons recorded intracellularly in vivo. Iontophoretically applied, morphine increased supra-threshold evoked depolarizing postsynaptic potentials inducing bursts of spikes, but only slightly increased weak (subthreshold) potentials. Spontaneous excitatory postsynaptic potentials were affected in a similar way, but their frequency did not change. Inhibitory postsynaptic potentials were only subsequently modified. Membrane hyperpolarization, induced by negative current injection, counteracts the morphine-induced burst generation. We suggest that the action of this alkaloid on threshold postsynaptic events involves a voltage-dependent mechanism, which may be triggered by synaptic currents.
AB - The action of morphine on spontaneous and stimulus-evoked postsynaptic potentials was investigated in rat cortical neurons recorded intracellularly in vivo. Iontophoretically applied, morphine increased supra-threshold evoked depolarizing postsynaptic potentials inducing bursts of spikes, but only slightly increased weak (subthreshold) potentials. Spontaneous excitatory postsynaptic potentials were affected in a similar way, but their frequency did not change. Inhibitory postsynaptic potentials were only subsequently modified. Membrane hyperpolarization, induced by negative current injection, counteracts the morphine-induced burst generation. We suggest that the action of this alkaloid on threshold postsynaptic events involves a voltage-dependent mechanism, which may be triggered by synaptic currents.
UR - http://www.scopus.com/inward/record.url?scp=0023808270&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023808270&partnerID=8YFLogxK
U2 - 10.1016/0306-4522(88)90126-1
DO - 10.1016/0306-4522(88)90126-1
M3 - Article
C2 - 3419591
AN - SCOPUS:0023808270
VL - 26
SP - 45
EP - 53
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
IS - 1
ER -