Morphine induces a spontaneous and evoked bursting activity in rat cortical neurons by adding a postsynaptic active mechanism to the synaptic input: An intracellular study In vivo

P. Stanzione, A. Stefani, G. Bernardi

Research output: Contribution to journalArticle

Abstract

The action of morphine on spontaneous and stimulus-evoked postsynaptic potentials was investigated in rat cortical neurons recorded intracellularly in vivo. Iontophoretically applied, morphine increased supra-threshold evoked depolarizing postsynaptic potentials inducing bursts of spikes, but only slightly increased weak (subthreshold) potentials. Spontaneous excitatory postsynaptic potentials were affected in a similar way, but their frequency did not change. Inhibitory postsynaptic potentials were only subsequently modified. Membrane hyperpolarization, induced by negative current injection, counteracts the morphine-induced burst generation. We suggest that the action of this alkaloid on threshold postsynaptic events involves a voltage-dependent mechanism, which may be triggered by synaptic currents.

Original languageEnglish
Pages (from-to)45-53
Number of pages9
JournalNeuroscience
Volume26
Issue number1
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Neuroscience(all)

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