Morphine is most effective on gastrointestinal propulsion in rats by intraperitoneal route: Evidence for local action

Alessandra Tavani, Giancarlo Bianchi, Patrizia Ferretti, Luciano Manara

Research output: Contribution to journalArticlepeer-review

Abstract

A very low dose of morphine (37.5 μg/kg) entirely delivered into the peritoneal cavity of rats, consistently reduced the transit of a forced charcoal meal through the small intestine (to about 30% of control), but failed to elicit such action in naloxone-pretreated animals or if administered either intravenously or intracerebroventricularly. The same dose of tritium labeled morphine, injected i.v., resulted in brain and small intestine morphine levels respectively 2.7 times higher and 3.9 times lower than in the corresponding tissues of rats injected i.p.. These findings suggest that activation of opiate specific sites located in the gastrointestinal tract can per se be primarily responsible for the antipropulsive effects of morphine.

Original languageEnglish
Pages (from-to)2211-2217
Number of pages7
JournalLife Sciences
Volume27
Issue number23
DOIs
Publication statusPublished - Dec 8 1980

ASJC Scopus subject areas

  • Pharmacology

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