Morphine no longer blocks gastrointestinal transit but retains antinociceptive action in diallylnormorphine-pretreated rats

Alessandra Tavani, Giancarlo Bianchi, Luciano Manara

Research output: Contribution to journalArticlepeer-review

Abstract

Diallylnormorphine (DANM) the quaternary N-allyl derivative of nalorphine, administered to rats, 8 mg/kg i.p., 20 min before i.v. injection of the potent opiate buprenorphine (1 μg/kg, tritrium-labeled), reduced in vivo binding of the latter (63% of controls at 30 min) in small intestine longitudinal muscle including myenteric plexus, but not in cerebrum. Naloxone, 1 mg/kg s.c., had the same effect of buprenorphine binding in the two sites (52 and 54% of controls respectively). The marked slowing in the transit of a forced charcoal meal through the small intestine of rats given 10 mg/kg morphine i.v. was prevented to comparable extents by DANM and naloxone; the latter also abolished the delay in hot plate reaction induced in these animals by morphine which, however, retained considerable antinociceptive effect in DANM-pretreated rats.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalEuropean Journal of Pharmacology
Volume59
Issue number1-2
DOIs
Publication statusPublished - Oct 26 1979

Keywords

  • H-Buprenorphine
  • Antinociception
  • Diallylnormorphine
  • Intestinal transit
  • Morphine
  • Naloxone

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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