Morphine withdrawal increases metabotropic glutamate 2/3 receptors expression in nucleus accumbens

Antonella M E Modafferi, Marco Diana, Ferdinando Nicoletti, Sergio Scaccianoce

Research output: Contribution to journalArticle

Abstract

We examined the effects of chronic morphine treatment and withdrawal on the expression of metabotropic glutamate (mGlu)1, mGlu5, and mGlu2/3 receptors in the nucleus accumbens and caudate putamen. Rats received a 14-day morphine treatment (escalating doses from 10 to 140 mg/kg). Receptor density was evaluated after chronic treatment and after 1, 3, and 14 days of withdrawal. mGlu1 and mGlu5 expression in the nucleus accumbens and in the caudate putamen was not affected by any of the experimental manipulations. In contrast, mGlu2/3 receptors in the nucleus accumbens, but not in the caudate putamen, increased at day 1, 3, and 14 of withdrawal. We suggest that an increased expression of mGlu2/3 receptors in the nucleus accumbens might contribute to the symptoms of morphine withdrawal.

Original languageEnglish
Pages (from-to)911-914
Number of pages4
JournalNeuroReport
Volume19
Issue number9
DOIs
Publication statusPublished - Jun 11 2008

Keywords

  • Caudate putamen
  • Drug addiction
  • Metabotropic glutamate receptors
  • Morphinewithdrawal
  • Nucleus accumbens

ASJC Scopus subject areas

  • Neuroscience(all)

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