Morpho-functional correlation of fundus autofluorescence in Stargardt disease

Maurizio Battaglia Parodi, Pierluigi Iacono, Giacinto Triolo, Carlo La Spina, Ilaria Zucchiatti, Maria Vittoria Cicinelli, Enrico Borrelli, Maria Pia Manitto, Elisabetta Martina, Francesco Bandello

Research output: Contribution to journalArticle

Abstract

Background: To correlate patterns in short-wavelength (SW) and near-infrared (NIR) fundus autofluorescence (FAF) with morpho-functional outcomes in eyes affected by Stargardt disease. Methods: Fifty-four eyes of 27 patients were prospectively enrolled. All patients underwent a complete ophthalmologic examination including SW-FAF, NIR-FAF, microperimetry and spectral-domain optical coherence tomography (SD-OCT). The main outcome measures were identification of a correlation between NIR-FAF and SW-FAF patterns within the foveal region and best corrected visual acuity (BCVA) values. Secondary outcome measures were correlation of FAF patterns with SD-OCT findings and retinal sensitivity on microperimetry. Results: Eyes showing a pattern of foveal hyper-FAF on NIR-FAF had a higher BCVA than eyes with a reduced FAF signal (0.44±0.23 LogMAR vs 1.08±0.19, p

Original languageEnglish
Pages (from-to)1354-1359
Number of pages6
JournalBritish Journal of Ophthalmology
Volume99
Issue number10
DOIs
Publication statusPublished - Oct 1 2015

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

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    Parodi, M. B., Iacono, P., Triolo, G., La Spina, C., Zucchiatti, I., Cicinelli, M. V., Borrelli, E., Pia Manitto, M., Martina, E., & Bandello, F. (2015). Morpho-functional correlation of fundus autofluorescence in Stargardt disease. British Journal of Ophthalmology, 99(10), 1354-1359. https://doi.org/10.1136/bjophthalmol-2014-306237