Morphofunctional aspects of tumor microcirculation

Domenico Ribatti

Research output: Book/ReportBook

Abstract

Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.

Original languageEnglish
PublisherSpringer Netherlands
Number of pages116
ISBN (Print)9789400749368, 940074935X, 9789400749351
DOIs
Publication statusPublished - May 1 2012

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Microcirculation
Microvessels
Basement Membrane
Endothelial Cells
Vascular Tissue Neoplasms
Pericytes
Tumor Microenvironment
Tumor Biomarkers
Growth
Cell Adhesion
Chromosome Aberrations
Blood Vessels
Permeability
Neoplasms
Bone Marrow
Pharmaceutical Preparations
Endothelial Progenitor Cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Morphofunctional aspects of tumor microcirculation. / Ribatti, Domenico.

Springer Netherlands, 2012. 116 p.

Research output: Book/ReportBook

Ribatti, Domenico. / Morphofunctional aspects of tumor microcirculation. Springer Netherlands, 2012. 116 p.
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