In irradiated hemopoietic tissues in vitro the formation of iso- and aniso-binu-cleated erythropoietic cells is caused by the failure of cytoplasm to divide and separate daughter nuclei reconstituted by the chromosomes of bi-pluri-ceiitric inetaphases and bi-pluri-polar ana-telophases. The size of the two nuclei, and the resulting iso- or aniso-nuclcarity, is in relation with the number of chromosomes from which each nucleus was reconstituted. Binuclcatcd cells may also result by fusion of the cytoplasm, of two neighbouring cells previously issued from a normal mitosis. Intrinsic mechanisms of the formation of binucleated cells are discussed.
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