Morphohistological features of pancreatic stump are the main determinant of pancreatic fistula after pancreatoduodenectomy

Cristina Ridolfi, Maria Rachele Angiolini, Francesca Gavazzi, Paola Spaggiari, Maria Carla Tinti, Fara Uccelli, Marco Madonini, Marco Montorsi, Alessandro Zerbi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Introduction. Pancreatic surgery is challenging and associated with high morbidity, mainly represented by postoperative pancreatic fistula (POPF) and its further consequences. Identification of risk factors for POPF is essential for proper postoperative management. Aim of the Study. Evaluation of the role of morphological and histological features of pancreatic stump, other than main pancreatic duct diameter and glandular texture, in POPF occurrence after pancreaticoduodenectomy. Patients and Methods. Between March 2011 and April 2013, we performed 145 consecutive pancreaticoduodenectomies. We intraoperatively recorded morphological features of pancreatic stump and collected data about postoperative morbidity. Our dedicated pathologist designed a score to quantify fibrosis and inflammation of pancreatic tissue. Results. Overall morbidity was 59,3%. Mortality was 4,1%. POPF rate was 28,3%, while clinically significant POPF were 15,8%. Male sex (P=0.009), BMI≥25 (P=0.002), prolonged surgery (P=0.001), soft pancreatic texture (P

Original languageEnglish
Article number641239
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

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Pancreatic Fistula
Pancreaticoduodenectomy
Surgery
Textures
Ducts
Morbidity
Tissue
Pancreatic Ducts
Fibrosis
Inflammation
Mortality

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Morphohistological features of pancreatic stump are the main determinant of pancreatic fistula after pancreatoduodenectomy. / Ridolfi, Cristina; Angiolini, Maria Rachele; Gavazzi, Francesca; Spaggiari, Paola; Tinti, Maria Carla; Uccelli, Fara; Madonini, Marco; Montorsi, Marco; Zerbi, Alessandro.

In: BioMed Research International, Vol. 2014, 641239, 2014.

Research output: Contribution to journalArticle

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abstract = "Introduction. Pancreatic surgery is challenging and associated with high morbidity, mainly represented by postoperative pancreatic fistula (POPF) and its further consequences. Identification of risk factors for POPF is essential for proper postoperative management. Aim of the Study. Evaluation of the role of morphological and histological features of pancreatic stump, other than main pancreatic duct diameter and glandular texture, in POPF occurrence after pancreaticoduodenectomy. Patients and Methods. Between March 2011 and April 2013, we performed 145 consecutive pancreaticoduodenectomies. We intraoperatively recorded morphological features of pancreatic stump and collected data about postoperative morbidity. Our dedicated pathologist designed a score to quantify fibrosis and inflammation of pancreatic tissue. Results. Overall morbidity was 59,3{\%}. Mortality was 4,1{\%}. POPF rate was 28,3{\%}, while clinically significant POPF were 15,8{\%}. Male sex (P=0.009), BMI≥25 (P=0.002), prolonged surgery (P=0.001), soft pancreatic texture (P",
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AU - Angiolini, Maria Rachele

AU - Gavazzi, Francesca

AU - Spaggiari, Paola

AU - Tinti, Maria Carla

AU - Uccelli, Fara

AU - Madonini, Marco

AU - Montorsi, Marco

AU - Zerbi, Alessandro

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AB - Introduction. Pancreatic surgery is challenging and associated with high morbidity, mainly represented by postoperative pancreatic fistula (POPF) and its further consequences. Identification of risk factors for POPF is essential for proper postoperative management. Aim of the Study. Evaluation of the role of morphological and histological features of pancreatic stump, other than main pancreatic duct diameter and glandular texture, in POPF occurrence after pancreaticoduodenectomy. Patients and Methods. Between March 2011 and April 2013, we performed 145 consecutive pancreaticoduodenectomies. We intraoperatively recorded morphological features of pancreatic stump and collected data about postoperative morbidity. Our dedicated pathologist designed a score to quantify fibrosis and inflammation of pancreatic tissue. Results. Overall morbidity was 59,3%. Mortality was 4,1%. POPF rate was 28,3%, while clinically significant POPF were 15,8%. Male sex (P=0.009), BMI≥25 (P=0.002), prolonged surgery (P=0.001), soft pancreatic texture (P

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