Morphologic, cytochemical and immunological profile in T-cell acute lymphoblastic leukemia of childhood

A. Cantù-Rajnoldi, G. Cattoretti, R. Schirò, M. Ferrari, S. Guercilena, S. Belforti, G. Masera

Research output: Contribution to journalArticle

Abstract

Twenty-one pediatric patients with T-cell acute lymphoblastic leukemia (T-ALL) were investigated for morphologic, cytochemical and immunological features at presentation and compared with 80 pediatric patients with not-T, non-B ALL observed in the same period. Immunophenotyping with a panel of monoclonal antibodies (VIL-A1, anti-HLA-DR, WT1, Lyt2, OKT3 and OKT6) revealed a heterogeneous pattern of expression in the T-ALL group. Five cases were characterized by absence of the E-receptor (E-rosette-, Lyt 3-) (E- T-ALL) and showed association in 3/5 with common-ALL antigen positivity and in 4/5 with Lyt2 and OKT6 positivity. E-receptor-positive cases (E-rosette+ and/or Lyt3+) (E+ T-ALL) all presented immunophenotypes corresponding to a known stage of intrathymic differentiation. Presence of hand mirror cells in the bone marrow was significantly related (p<0.05) with T-ALL and within the T-ALL appeared to be especially associated with E- T-ALL (5/5 cases). PAS negativity was significantly related to T-ALL as compared to non-T, non-B ALL (p<0.05), whereas no significant difference in frequency was found for L1 or L2 FAB subgroups and acid aplhanaphthyl acetate esterase in T-ALL as compared to non-T, non-B ALL. Acid phosphatase focal positivity was found in 19/20 T-ALL but not in any non-T, non-B ALL, including three cases of non-T, non-B, common-ALL antigen positive ALL in which unusual expression of the E-receptor (E-rosette+, Lyt3+) was detected.

Original languageEnglish
Pages (from-to)467-472
Number of pages6
JournalHaematologica
Volume71
Issue number6
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Hematology

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    Cantù-Rajnoldi, A., Cattoretti, G., Schirò, R., Ferrari, M., Guercilena, S., Belforti, S., & Masera, G. (1986). Morphologic, cytochemical and immunological profile in T-cell acute lymphoblastic leukemia of childhood. Haematologica, 71(6), 467-472.