Twenty-one pediatric patients with T-cell acute lymphoblastic leukemia (T-ALL) were investigated for morphologic, cytochemical and immunological features at presentation and compared with 80 pediatric patients with not-T, non-B ALL observed in the same period. Immunophenotyping with a panel of monoclonal antibodies (VIL-A1, anti-HLA-DR, WT1, Lyt2, OKT3 and OKT6) revealed a heterogeneous pattern of expression in the T-ALL group. Five cases were characterized by absence of the E-receptor (E-rosette-, Lyt 3-) (E- T-ALL) and showed association in 3/5 with common-ALL antigen positivity and in 4/5 with Lyt2 and OKT6 positivity. E-receptor-positive cases (E-rosette+ and/or Lyt3+) (E+ T-ALL) all presented immunophenotypes corresponding to a known stage of intrathymic differentiation. Presence of hand mirror cells in the bone marrow was significantly related (p<0.05) with T-ALL and within the T-ALL appeared to be especially associated with E- T-ALL (5/5 cases). PAS negativity was significantly related to T-ALL as compared to non-T, non-B ALL (p<0.05), whereas no significant difference in frequency was found for L1 or L2 FAB subgroups and acid aplhanaphthyl acetate esterase in T-ALL as compared to non-T, non-B ALL. Acid phosphatase focal positivity was found in 19/20 T-ALL but not in any non-T, non-B ALL, including three cases of non-T, non-B, common-ALL antigen positive ALL in which unusual expression of the E-receptor (E-rosette+, Lyt3+) was detected.
|Number of pages||6|
|Publication status||Published - 1986|
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