TY - JOUR
T1 - Morphologic evaluation of the liver in hereditary angioedema patients on long-term treatment with androgen derivatives
AU - Cicardi, Marco
AU - Bergamaschini, Luigi
AU - Tucci, Antonietta
AU - Agostoni, Angelo
AU - Tornaghi, Giulio
AU - Coggi, Guide
AU - Colombi, Roberto
AU - Viale, Giuseppe
PY - 1983
Y1 - 1983
N2 - 17α-Alkylated androgens are highly effective in preventing attacks in HAE patients. These drugs, however, seem to be implicated in the development of cholestatic jaundice, peliosis hepatis, and liver tumors. In order to assess the risk-benefit balance of the long-term therapy with androgen derivatives, a follow-up investigation was performed in 13 HAE patients. The results of this study indicate that long-term treatment (15 to 47 mo) with low doses of danazol or stanozolol does not induce significant hepatic damage detectable by laboratory tests or liver biopsy. However, the limited number of patients, although in a rather long period of observation, still suggests a careful control and the use of minimal effective doses.
AB - 17α-Alkylated androgens are highly effective in preventing attacks in HAE patients. These drugs, however, seem to be implicated in the development of cholestatic jaundice, peliosis hepatis, and liver tumors. In order to assess the risk-benefit balance of the long-term therapy with androgen derivatives, a follow-up investigation was performed in 13 HAE patients. The results of this study indicate that long-term treatment (15 to 47 mo) with low doses of danazol or stanozolol does not induce significant hepatic damage detectable by laboratory tests or liver biopsy. However, the limited number of patients, although in a rather long period of observation, still suggests a careful control and the use of minimal effective doses.
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U2 - 10.1016/0091-6749(83)90034-9
DO - 10.1016/0091-6749(83)90034-9
M3 - Article
C2 - 6886261
AN - SCOPUS:0020603640
VL - 72
SP - 294
EP - 298
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 3
ER -