Morphologic, immunologic, and cytogenetic characteristics of secondary acute unclassifiable leukemia in Hodgkin's disease

A. Orazi, G. Cattoretti, G. Sozzi, M. Miozzo, N. Polli, D. Delia, S. Viviani, E. Negretti, G. Della Porta, F. Rilke

Research output: Contribution to journalArticlepeer-review

Abstract

Blast cells from five cases of secondary unclassifiable leukemia following therapy for Hodgkin's disease were studied by cytochemical, immunological and cytogenetic analyses. Cytochemical and immunological reactivity were in accordance with poorly differentiated, myeloid blasts. The four cases in which karyotype analysis was performed showed specific chromosomal abnormalities. No evidence of multiple lineage involvement was found. Problems in classifying these cases of secondary ANLL were due to the high grade of undifferentiation of the blast cells. Their low cytochemical reactivity with markers of myeloid differentiation was similar to what may be observed in patients with acute undifferentiated leukemia or with chronic myeloid leukemia in blast crisis.

Original languageEnglish
Pages (from-to)439-450
Number of pages12
JournalTumori
Volume74
Issue number4
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Cancer Research

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