Morphological alterations induced by loud noise in the myocardium

The role of benzodiazepine receptors

Marco Gesi, Francesco Fornai, Paola Lenzi, Michela Ferrucci, Paola Soldani, Riccardo Ruffoli, Antonio Paparelli

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Noise represents an environmental stress factor affecting several organs and apparati, including the cardiovascular system. In experimental animals undergoing noise exposure, subcellular myocardial changes have been reported, especially at mitochondrial level; in particular, after 6 hours of exposure only the atrium exhibited significant mitochondrial alterations, whereas after 12 hours as well as subchronic exposure both atrium and ventricle were damaged. The first part of the present article overviews the experimental evidence on effects of noise on the myocardium. In the second part, the review analyzes the role of benzodiazepine receptors and the potential efficacy of benzodiazepine ligands in preventing the mitochondrial damage induced by noise exposure. Drugs acting at both central and peripheral benzodiazepine receptors significantly prevent this damage. Differences in the amount and the duration of the protective effect might depend on variability in the potency and pharmacokinetics of the specific drug. The effects of the combined treatment with selective and non-selective peripheral benzodiazepine ligands on noise stimulation are discussed at biochemical level reviewing studies on the effects of noise exposure on mitochondrial fractions.

Original languageEnglish
Pages (from-to)136-146
Number of pages11
JournalMicroscopy Research and Technique
Volume59
Issue number2
DOIs
Publication statusPublished - Oct 15 2002

Fingerprint

myocardium
benzodiazepines
GABA-A Receptors
Noise
Myocardium
Ligands
Cardiovascular system
receptors
Pharmacokinetics
Animals
Benzodiazepines
drugs
subchronic exposure
damage
cardiovascular system
ligands
reviewing
Cardiovascular System
stimulation
organs

Keywords

  • Electron microscopy
  • Heart
  • Mitochondria
  • Rat
  • Stress

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

Cite this

Morphological alterations induced by loud noise in the myocardium : The role of benzodiazepine receptors. / Gesi, Marco; Fornai, Francesco; Lenzi, Paola; Ferrucci, Michela; Soldani, Paola; Ruffoli, Riccardo; Paparelli, Antonio.

In: Microscopy Research and Technique, Vol. 59, No. 2, 15.10.2002, p. 136-146.

Research output: Contribution to journalArticle

Gesi, Marco ; Fornai, Francesco ; Lenzi, Paola ; Ferrucci, Michela ; Soldani, Paola ; Ruffoli, Riccardo ; Paparelli, Antonio. / Morphological alterations induced by loud noise in the myocardium : The role of benzodiazepine receptors. In: Microscopy Research and Technique. 2002 ; Vol. 59, No. 2. pp. 136-146.
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