Morphological and functional changes in recalcitrant diabetic macular oedema after intravitreal dexamethasone implant

P Iacono, M Battaglia Parodi, Matteo Scaramuzzi, F Bandello

Research output: Contribution to journalArticlepeer-review

Abstract

Background To evaluate the effects of dexamethasone implant in eyes affected by recalcitrant diabetic macular oedema (DME) associated with proliferative diabetic retinopathy (PDR). Methods Thirteen consecutive patients with centreinvolving DME associated with PDR, central macular thickness (CMT) =300 mm, previous therapy with panretinal photocoagulation, focal/grid laser treatment and anti-vascular endothelial growth factor injection were prospectively enrolled. A complete ophthalmological examination included: best-corrected visual acuity (BCVA) assessment, spectral-domain optical coherence tomography and fluorescein angiography. After the first dexamethasone implant, each patient was evaluated on a bi-monthly basis and re-treated according to persistence/recurrence of DME from the fourth month on. Primary outcome measures were the changes in mean BCVA and CMT at the 12-month examination. Secondary outcome measures included changes to the outer retinal layers. Results BCVA improved from 0.99±0.31 LogMAR (logarithm of the minimum angle of resolution; Snellen Equivalent: 20/196) to 0.77±0.25 LogMAR (Snellen Equivalent: 20/117) ( p
Original languageEnglish
Pages (from-to)791-795
Number of pages5
JournalBritish Journal of Ophthalmology
Volume101
Issue number6
DOIs
Publication statusPublished - 2017

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