Morphological and hemostatic changes in rats with abdominal arterial prosthesis

Ewa Chabielska, Valeri Kolpakov, Maria Cristina D'Adamo, Amalia De Curtis, Wlodzimierz Buczko, Licia Iacoviello, Maria Benedetta Donati

Research output: Contribution to journalArticle

Abstract

We evaluated the changes over time in hemostatic factors during ongoing arterial thrombosis in rats, as induced by a loop-shaped aortic prosthesis. Moreover, we investigated this condition by inspecting in parallel local thrombus growth, systemic vascular prostacyclin and t-PA production. One minute after loop insertion, activated platelets spread on the internal surface of the prosthesis and 24 hrs later numerous platelet aggregates supported by a fibrin network could be observed. However, no evidence for platelet activation could be concomitantly found in peripheral blood. A sustained increase in PGI2 formation was detected together with a progressive increase in plasma fibrinolytic activity during thrombus growth. The levels of fibrinogen as well as antithrombin III (ATIII) and heparin cofactor II (HCII) activities were steadily increased in loop-bearing animals. In conclusion, the dynamic phases of thrombus formation, in an aortic prosthesis, produce changes in vascular function and in hemostatic factors at the level of systemic blood.

Original languageEnglish
Pages (from-to)69-77
Number of pages9
JournalThrombosis Research
Volume82
Issue number1
DOIs
Publication statusPublished - Apr 1 1996

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Keywords

  • arterial thrombosis
  • hemostasis
  • rat

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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