Morphological and pathological features of basal-like breast cancer

Gerardo Botti; Monica Cantile; Francesca Collina; Margherita Cerrone; Sabrina Sarno; Annamaria Anniciello; Maurizio Di Bonito

doi:10.21037/tcr.2019.06.50

Morphological and pathological features of basal-like breast cancer

Gerardo Botti, Monica Cantile, Francesca Collina, Margherita Cerrone, Sabrina Sarno, Annamaria Anniciello, Maurizio Di Bonito

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Basal-like breast cancer (BLBC) is characterized by high grade, high mitotic indices, presence of central necrotic or fibrotic zones, and lymphocytic infiltrate. Patients presenting with BLBC have a poor prognosis and a short-term disease-free and overall survival. BLBCs may include different histological types of breast cancers but the most common histological type is represented by invasive ductal carcinomas of no special type (IDC-NST). Typical immunohistochemical markers for these tumors are basal-type cytokeratin markers such as CK5/6, CK14, CK17, but several BLBCs also express luminal-type CKs, such as CK8/18, CK19. Different molecular alterations, including BRCA1 dysfunction, p53 mutations, up-regulation of EGFR, inactivation of PTEN and the aberrant expression of many non-coding RNAs molecules are detected in BLBC cells suggesting the possibility of defining new targeted therapeutic strategies for this tumor type.

Original language	English
Pages (from-to)	S503-S509
Journal	Translational Cancer Research
Volume	8
Issue number	5
DOIs	https://doi.org/10.21037/tcr.2019.06.50
Publication status	Published - Oct 1 2019

Keywords

Basal-like breast cancer (BLBC)
histological features
molecular markers

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title = "Morphological and pathological features of basal-like breast cancer",

abstract = "Basal-like breast cancer (BLBC) is characterized by high grade, high mitotic indices, presence of central necrotic or fibrotic zones, and lymphocytic infiltrate. Patients presenting with BLBC have a poor prognosis and a short-term disease-free and overall survival. BLBCs may include different histological types of breast cancers but the most common histological type is represented by invasive ductal carcinomas of no special type (IDC-NST). Typical immunohistochemical markers for these tumors are basal-type cytokeratin markers such as CK5/6, CK14, CK17, but several BLBCs also express luminal-type CKs, such as CK8/18, CK19. Different molecular alterations, including BRCA1 dysfunction, p53 mutations, up-regulation of EGFR, inactivation of PTEN and the aberrant expression of many non-coding RNAs molecules are detected in BLBC cells suggesting the possibility of defining new targeted therapeutic strategies for this tumor type.",

keywords = "Basal-like breast cancer (BLBC), histological features, molecular markers",

author = "Gerardo Botti and Monica Cantile and Francesca Collina and Margherita Cerrone and Sabrina Sarno and Annamaria Anniciello and {Di Bonito}, Maurizio",

year = "2019",

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doi = "10.21037/tcr.2019.06.50",

language = "English",

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T1 - Morphological and pathological features of basal-like breast cancer

AU - Botti, Gerardo

AU - Cantile, Monica

AU - Collina, Francesca

AU - Cerrone, Margherita

AU - Sarno, Sabrina

AU - Anniciello, Annamaria

AU - Di Bonito, Maurizio

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Basal-like breast cancer (BLBC) is characterized by high grade, high mitotic indices, presence of central necrotic or fibrotic zones, and lymphocytic infiltrate. Patients presenting with BLBC have a poor prognosis and a short-term disease-free and overall survival. BLBCs may include different histological types of breast cancers but the most common histological type is represented by invasive ductal carcinomas of no special type (IDC-NST). Typical immunohistochemical markers for these tumors are basal-type cytokeratin markers such as CK5/6, CK14, CK17, but several BLBCs also express luminal-type CKs, such as CK8/18, CK19. Different molecular alterations, including BRCA1 dysfunction, p53 mutations, up-regulation of EGFR, inactivation of PTEN and the aberrant expression of many non-coding RNAs molecules are detected in BLBC cells suggesting the possibility of defining new targeted therapeutic strategies for this tumor type.

AB - Basal-like breast cancer (BLBC) is characterized by high grade, high mitotic indices, presence of central necrotic or fibrotic zones, and lymphocytic infiltrate. Patients presenting with BLBC have a poor prognosis and a short-term disease-free and overall survival. BLBCs may include different histological types of breast cancers but the most common histological type is represented by invasive ductal carcinomas of no special type (IDC-NST). Typical immunohistochemical markers for these tumors are basal-type cytokeratin markers such as CK5/6, CK14, CK17, but several BLBCs also express luminal-type CKs, such as CK8/18, CK19. Different molecular alterations, including BRCA1 dysfunction, p53 mutations, up-regulation of EGFR, inactivation of PTEN and the aberrant expression of many non-coding RNAs molecules are detected in BLBC cells suggesting the possibility of defining new targeted therapeutic strategies for this tumor type.

KW - Basal-like breast cancer (BLBC)

KW - histological features

KW - molecular markers

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