TY - JOUR
T1 - Morphological and pathological features of basal-like breast cancer
AU - Botti, Gerardo
AU - Cantile, Monica
AU - Collina, Francesca
AU - Cerrone, Margherita
AU - Sarno, Sabrina
AU - Anniciello, Annamaria
AU - Di Bonito, Maurizio
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Basal-like breast cancer (BLBC) is characterized by high grade, high mitotic indices, presence of central necrotic or fibrotic zones, and lymphocytic infiltrate. Patients presenting with BLBC have a poor prognosis and a short-term disease-free and overall survival. BLBCs may include different histological types of breast cancers but the most common histological type is represented by invasive ductal carcinomas of no special type (IDC-NST). Typical immunohistochemical markers for these tumors are basal-type cytokeratin markers such as CK5/6, CK14, CK17, but several BLBCs also express luminal-type CKs, such as CK8/18, CK19. Different molecular alterations, including BRCA1 dysfunction, p53 mutations, up-regulation of EGFR, inactivation of PTEN and the aberrant expression of many non-coding RNAs molecules are detected in BLBC cells suggesting the possibility of defining new targeted therapeutic strategies for this tumor type.
AB - Basal-like breast cancer (BLBC) is characterized by high grade, high mitotic indices, presence of central necrotic or fibrotic zones, and lymphocytic infiltrate. Patients presenting with BLBC have a poor prognosis and a short-term disease-free and overall survival. BLBCs may include different histological types of breast cancers but the most common histological type is represented by invasive ductal carcinomas of no special type (IDC-NST). Typical immunohistochemical markers for these tumors are basal-type cytokeratin markers such as CK5/6, CK14, CK17, but several BLBCs also express luminal-type CKs, such as CK8/18, CK19. Different molecular alterations, including BRCA1 dysfunction, p53 mutations, up-regulation of EGFR, inactivation of PTEN and the aberrant expression of many non-coding RNAs molecules are detected in BLBC cells suggesting the possibility of defining new targeted therapeutic strategies for this tumor type.
KW - Basal-like breast cancer (BLBC)
KW - histological features
KW - molecular markers
U2 - 10.21037/tcr.2019.06.50
DO - 10.21037/tcr.2019.06.50
M3 - Article
VL - 8
SP - S503-S509
JO - Translational Cancer Research
JF - Translational Cancer Research
SN - 2218-676X
IS - 5
ER -